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Reference: Gibani, MM, Jin, C, Darton, TC et al., (2015). Control of invasive Salmonella disease in Africa: is there a role for human challenge models?. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 61 Suppl 4, S266-S271.Citable link to this page:

 

Control of invasive Salmonella disease in Africa: is there a role for human challenge models?

Abstract: Invasive Salmonella disease in Africa is a major public health concern. With evidence of the transcontinental spread of the Salmonella Typhi H58 haplotype, improved estimates of the burden of infection and understanding of the complex interplay of factors affecting disease transmission are needed to assist with efforts aimed at disease control. In addition to Salmonella Typhi, invasive nontyphoidal Salmonella are increasingly recognized as an important cause of febrile illness and mortality in sub-Saharan Africa. Human experimental oral challenge studies with Salmonella can be used as a model to offer unique insights into host-pathogen interactions as well as a platform to efficiently test new diagnostic and vaccine candidates. In this article, we review the background and use of human challenge studies to date and discuss how findings from these studies may lead to progress in the control of invasive Salmonella disease in Africa.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: NationalInstitutes for Health Research Oxford Biomedical Research Centre   Funder: Wellcome Trust   Funder: Bill and Melinda Gates Foundation   Funder: EuropeanVaccine Initiative   Funder: Medical Research Council   Notes:Copyright © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: Oxford University Press

Publisher Website: http://www.oxfordjournals.org/

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of Americasee more from them

Publication Website: http://cid.oxfordjournals.org/

Issue Date: 2015-11

pages:S266-S271Identifiers

Urn: uuid:7855a609-0b61-4ac0-88f3-4a5d076089d7

Source identifier: 572902

Eissn: 1537-6591

Doi: https://doi.org/10.1093/cid/civ673

Issn: 1058-4838 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Salmonella Typhi controlled human infection study human challenge study invasive nontyphoidal Salmonella typhoid fever Tiny URL: pubs:572902

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Autor: Gibani, MM - institutionUniversity of Oxford Oxford, MSD, Paediatrics - - - Jin, C - institutionUniversity of Oxford Oxford, MSD,

Fuente: https://ora.ox.ac.uk/objects/uuid:7855a609-0b61-4ac0-88f3-4a5d076089d7



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