Matched sizes of activating and inhibitory receptor-ligand pairs are required for optimal signal integration by human natural killer cells.Reportar como inadecuado




Matched sizes of activating and inhibitory receptor-ligand pairs are required for optimal signal integration by human natural killer cells. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Reference: Köhler, K, Xiong, S, Brzostek, J et al., (2010). Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells. PloS one, 5 (11), e15374.Citable link to this page:

 

Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human natural killer cells.

Abstract: It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling. Here, we set out to test the importance of receptor-ligand complex dimensions for immune surveillance of target cells by human Natural Killer (NK) cells. NK cell activation is regulated by integrating signals from activating receptors, such as NKG2D, and inhibitory receptors, such as KIR2DL1. Elongating the NKG2D ligand MICA reduced its ability to trigger NK cell activation. Conversely, elongation of KIR2DL1 ligand HLA-C reduced its ability to inhibit NK cells. Whereas normal-sized HLA-C was most effective at inhibiting activation by normal-length MICA, only elongated HLA-C could inhibit activation by elongated MICA. Moreover, HLA-C and MICA that were matched in size co-localised, whereas HLA-C and MICA that were different in size were segregated. These results demonstrate that receptor-ligand dimensions are important in NK cell recognition, and suggest that optimal integration of activating and inhibitory receptor signals requires the receptor-ligand complexes to have similar dimensions.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Biotechnology and Biological Sciences Research Council   Funder: Medical Research Council   Funder: Wolfson Royal Society   Notes:Copyright 2010 Kohler et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Bibliographic Details

Publisher: Public Library of Science

Publisher Website: http://www.plos.org

Journal: PloS onesee more from them

Publication Website: http://www.plosone.org

Issue Date: 2010

Article Number:ARTN e15374

pages:e15374Identifiers

Urn: uuid:8cec9f15-3067-4848-b78f-c49c5f9f10cb

Source identifier: 107082

Eissn: 1932-6203

Doi: https://doi.org/10.1371/journal.pone.0015374

Issn: 1932-6203 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Humans Cell Line Recombinant Fusion Proteins Luminescent Proteins Ligands Microscopy, Confocal Histocompatibility Antigens Class I HLA-C Antigens Signal Transduction Lymphocyte Activation Protein Binding Amino Acid Sequence Molecular Sequence Data Killer Cells, Natural Receptors, KIR2DL1 NK Cell Lectin-Like Receptor Subfamily K Tiny URL: pubs:107082

Relationships





Autor: Köhler, K - - - Xiong, S - - - Brzostek, J - - - Mehrabi, M - - - Eissmann, P - - - Harrison, A - - - Cordoba, SP - - - Oddos, S

Fuente: https://ora.ox.ac.uk/objects/uuid:8cec9f15-3067-4848-b78f-c49c5f9f10cb



DESCARGAR PDF




Documentos relacionados