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Reference: Turri, Maria Grazia, (2002). Mapping of behavioural quantitative trait loci. DPhil. University of Oxford.Citable link to this page:

 

Mapping of behavioural quantitative trait loci

Abstract: Anxiety is a common disorder which affects about 25% of the population and whosepathophysiology is still poorly understood. Animal models of disease have been widelyused to investigate the molecular basis of human disorders, including psychiatric illnesses.This thesis is about the study of the genetic basis of a mouse model of anxiety.I have carried out a QTL mapping study of behavioural measures thought to model anxiety.I report results from 1,636 mice, assessed for a large number of phenotypes in fiveethological tests. Mice belonged to two F2 intercrosses originated by four lines generated ina replicate selection experiment. By comparing mapping results between the two crosses, Ihave demonstrated that selection operated on the same relatively small number of loci inthe four selected lines.Analysis of genetic effect of QTL across phenotypes has allowed me to identify loci withspecific roles on different dimensions of anxious behaviour, therefore enhancing ourunderstanding of the anxiety phenotype in mice. For some of these QTL I have alsoaccomplished fine mapping experiments: a locus on chromosome 15 is now contained inan interval of only 3 centimorgans.This work is the basis for further molecular dissection of the genetic loci that underlieanxiety and provides a starting point for the discovery of genes involved in a commonpsychiatric condition.

Type of Award:DPhil Level of Award:Doctoral Awarding Institution: University of Oxford Notes:This thesis was digitised thanks to the generosity of Dr Leonard PolonskyNotes:Some images have been removed from the downloadable file. To view the full thesis please contact the ORA team.

Contributors

Flint, JonathanMore by this contributor

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Jonathan FlintMore by this contributor

RoleSupervisor

 Bibliographic Details

Issue Date: 2002Identifiers

Urn: uuid:89823fa1-c1d3-49e3-acb9-46da18b12245

Source identifier: 603838277 Item Description

Type: Thesis;

Language: eng Subjects: Anxiety Research Phenotype Mice Physiology Tiny URL: td:603838277

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Autor: Turri, Maria Grazia - institutionUniversity of Oxford facultyMedical Sciences Division - - - - Contributors Flint, Jonathan More

Fuente: https://ora.ox.ac.uk/objects/uuid:89823fa1-c1d3-49e3-acb9-46da18b12245



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