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Reference: Renton, T, Yiangou, Y, Plumpton, C et al., (2005). Sodium channel Nav1.8 immunoreactivity in painful human dental pulp. BMC oral health, 5 (1), 5.Citable link to this page:

 

Sodium channel Nav1.8 immunoreactivity in painful human dental pulp.

Abstract: Background: The tetrodotoxin-resistant voltage-gated sodium channel Nav1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states.Methods: Using specific antibodies for immunohistochemistry, we studied Nav1.8 – immunoreactivity in human dental pulp in relation to the neuronal marker neurofilament. Human tooth pulp was extracted from teeth harvested from a total of twenty-two patients (fourteen without dental pain, eight patients with dental pain).Results: Fibres immunoreactive for Nav1.8, were significantly increased on image analysis in the painful group: median (range) Nav1.8 to Neurofilament % area ratio, non-painful 0.059 (0.006–0.24), painful 0.265 (0.13–0.5), P = 0.0019.Conclusion: Nav1.8 sodium channels may thus represent a therapeutic target in trigeminal nerve pain states.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:© 2005 Renton et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: BioMed Central Ltd.

Publisher Website: http://www.biomedcentral.com/

Journal: BMC oral healthsee more from them

Publication Website: http://www.biomedcentral.com/bmcoralhealth/

Issue Date: 2005-7

pages:5Identifiers

Urn: uuid:903a48ee-c653-4ece-a37b-c36b2266b52d

Source identifier: 33157

Eissn: 1472-6831

Doi: https://doi.org/10.1186/1472-6831-5-5

Issn: 1472-6831 Item Description

Type: Journal article;

Language: eng

Version: Publisher's version Tiny URL: pubs:33157

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Autor: Renton, T - - - Yiangou, Y - - - Plumpton, C - - - Tate, S - - - Bountra, C - institutionUniversity of Oxford Oxford, MSD, Clinic

Fuente: https://ora.ox.ac.uk/objects/uuid:903a48ee-c653-4ece-a37b-c36b2266b52d



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