Bayesian algorithms for recovering structure from single-particle diffraction snapshots of unknown orientation: a comparison - Condensed Matter > Soft Condensed MatterReportar como inadecuado




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Abstract: The advent of X-ray Free Electron Lasers promises the possibility todetermine the structure of individual particles such as microcrystallites,viruses and biomolecules from single-shot diffraction snapshots obtained beforethe particle is destroyed by the intense femtosecond pulse. This programrequires the ability to determine the orientation of the particle giving riseto each snapshot at signal levels as low as ~10-2 photons-pixel. Two apparentlydifferent approaches have recently demonstrated this capability. Here we showthey represent different implementations of the same fundamental approach, andidentify the primary factors limiting their performance.



Autor: Brian Moths, Abbas Ourmazd

Fuente: https://arxiv.org/







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