Genomic analysis of local variation and recent evolution in Plasmodium vivaxReportar como inadecuado




Genomic analysis of local variation and recent evolution in Plasmodium vivax - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Reference: Kwiatkowski, DP, Pearson, RD, Amato, R et al., (2016). Genomic analysis of local variation and recent evolution in Plasmodium vivax. Nature Genetics, 48, 959–964.Citable link to this page:

 

Genomic analysis of local variation and recent evolution in Plasmodium vivax

Abstract: The widespread distribution and relapsing nature of Plasmodium vivax infection present major challenges for malaria elimination. To characterise the genetic diversity of this parasite within individual infections and across the population, we performed deep genome sequencing of >200 clinical samples collected across the Asia-Pacific region, and analysed data on >300,000 SNPs and 9 regions of the genome with large structural variations. Individual infections showed complex patterns of genetic structure, with variation not only in the number of dominant clones but also in their level of relatedness and inbreeding. At the population level, we observed strong signals of recent evolutionary selection both in known drug resistance genes and at novel loci, and these varied markedly between geographical locations. These findings reveal a dynamic landscape of local evolutionary adaptation in P. vivax populations, and provide a foundation for genomic surveillance to guide effective strategies for control and elimination.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Accepted manuscript Funder: Wellcome Trust   Funder: Medical Research Council   Funder: UK Department for International Development   Notes:© 2016 Nature America, Inc. All rights reserved

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website: http://www.nature.com/

Journal: Nature Geneticssee more from them

Publication Website: http://www.nature.com/ng/

Volume: 48

Extent: 959–964

Issue Date: 2016

pages:959–964Identifiers

Urn: uuid:9dd25c92-466b-4ff6-a56e-d9b7f5a20d25

Source identifier: 617207

Eissn: 1546-1718

Issn: 1061-4036

Doi: https://doi.org/10.1038/ng.3599 Item Description

Type: Journal article;

Version: Accepted manuscript Tiny URL: pubs:617207

Relationships





Autor: Kwiatkowski, DP - institutionUniversity of Oxford Oxford, MSD, NDM, NDM Strategic - - - Pearson, RD - institutionUniversity of Ox

Fuente: https://ora.ox.ac.uk/objects/uuid:9dd25c92-466b-4ff6-a56e-d9b7f5a20d25



DESCARGAR PDF




Documentos relacionados