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Reference: Depoil, D and Dustin, ML, (2016). Agile CD22 nanoclusters run rings around fenced BCR. EMBO Journal, 35 (3), 237-238.Citable link to this page:


Agile CD22 nanoclusters run rings around fenced BCR.

Abstract: B lymphocytes are key players in host defence, but also autoimmune diseases. Their survival depends upon tonic signals transduced by surface immunoglobulin (BCR) and the process leading to antibody secretion is initiated by interaction of BCR with a cognate antigen. CD22 limits signalling of the BCR to strike a balance between tonic signalling, reactivity to pathogens and prevention of autoimmunity. In this issue, Gasparrini et al (2016) combined super‐resolution imaging approaches with single‐particle tracking and simulations to show how CD22 controls the signalling state of the BCR. They demonstrated that small CD22 nanoclusters run rings around the BCR in confined steady state to maintain low tonic signals, but releasing BCR from these corrals allows BCR cluster growth, which overcomes the harrying inhibition from highly mobile CD22.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Accepted manuscriptNotes:© 2016 The Authors. Published under the terms of the CC BY 4.0 license.

Bibliographic Details

Publisher: EMBO Press

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Journal: EMBO Journalsee more from them

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Issue Date: 2016-01-08


Urn: uuid:a9ba0aac-f3a8-4c56-8729-29ebda2c3782

Source identifier: 587032

Eissn: 1460-2075


Issn: 0261-4189 Item Description

Type: Journal article;

Language: eng

Version: Accepted manuscript Tiny URL: pubs:587032


Autor: Depoil, D - institutionUniversity of Oxford Oxford, MSD, NDORMS, KIR - - - Dustin, ML - institutionUniversity of Oxford Oxford, M



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