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Reference: Travis, SP, Schnell, D, Feagan, BG et al., (2015). The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS]. Journal of Crohn's and colitis, 9 (8), 607-616.Citable link to this page:

 

The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].

Abstract: BACKGROUND AND AIMS: To determine whether clinical information influences endoscopic scoring by central readers using the Ulcerative Colitis Endoscopic Index of Severity [UCEIS; comprising 'vascular pattern', 'bleeding', 'erosions and ulcers']. METHODS: Forty central readers performed 28 evaluations, including 2 repeats, from a library of 44 video sigmoidoscopies stratified by Mayo Clinic Score. Following training, readers were randomised to scoring with ['unblinded', n = 20, including 4 control videos with misleading information] or without ['blinded', n 20] clinical information. A total of 21 virtual Central Reader Groups [CRGs], of three blinded readers, were created. Agreement criteria were pre-specified. Kappa [κ] statistics quantified intra- and inter-reader variability. RESULTS: Mean UCEIS scores did not differ between blinded and unblinded readers for any of the 40 main videos. UCEIS standard deviations [SD] were similar [median blinded 0.94, unblinded 0.93; p = 0.97]. Correlation between UCEIS and visual analogue scale [VAS] assessment of overall severity was high [r blinded = 0.90, unblinded = 0.93; p = 0.02]. Scores for control videos were similar [UCEIS: p ≥ 0.55; VAS: p ≥ 0.07]. Intra- [κ 0.47-0.74] and inter-reader [κ 0.40-0.53] variability for items and full UCEIS was 'moderate'-to-'substantial', with no significant differences except for intra-reader variability for erosions and ulcers [κ blinded: 0.47 vs unblinded: 0.74; p 0.047]. The SD of CRGs was lower than for individual central readers [0.54 vs 0.95; p < 0.001]. Correlation between blinded UCEIS and patient-reported symptoms was high [stool frequency: 0.76; rectal bleeding: 0.82; both: 0.81]. CONCLUSIONS: The UCEIS is minimally affected by knowledge of clinical details, strongly correlates with patient-reported symptoms, and is a suitable instrument for trials. CRGs performed better than individuals.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Warner Chilcott/Actavis   Notes:Copyright © European Crohn's and Colitis Organisation 2015.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/),which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: Oxford University Press

Publisher Website: http://www.oxfordjournals.org/

Journal: Journal of Crohn's and colitissee more from them

Publication Website: http://ecco-jcc.oxfordjournals.org/

Issue Date: 2015-05

pages:607-616Identifiers

Urn: uuid:a918757e-c272-40c6-9965-3aa02116495d

Source identifier: 523253

Eissn: 1876-4479

Doi: https://doi.org/10.1093/ecco-jcc/jjv077

Issn: 1873-9946 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Endoscopic score disease activity index ulcerative colitis Tiny URL: pubs:523253

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Autor: Travis, SP - institutionUniversity of Oxford Oxford, MSD, Clinical Medicine, Experimental Medicine - - - Schnell, D - - - Feagan,

Fuente: https://ora.ox.ac.uk/objects/uuid:a918757e-c272-40c6-9965-3aa02116495d



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