Global changes of the RNA-bound proteome during thematernal-to-zygotic transition in DrosophilaReportar como inadecuado




Global changes of the RNA-bound proteome during thematernal-to-zygotic transition in Drosophila - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Reference: Castello Palomares, A, Sysoev, VO, Fischer, B et al., (2016). Global changes of the RNA-bound proteome during thematernal-to-zygotic transition in Drosophila. Nature Communications.Citable link to this page:

 

Global changes of the RNA-bound proteome during thematernal-to-zygotic transition in Drosophila

Abstract: The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the earliest developmental stages, during which maternally deposited mRNAs and other molecules are degraded and replaced by products of the zygotic genome. The zygotic genome is not activated immediately upon fertilization, and in the pre-MZT embryo post-transcriptional control by RNA-binding proteins (RBPs) orchestrates the first steps of development. To identify relevant Drosophila RPBs organism-wide, we refined the RNA interactome capture method for comparative analysis of pre- and post-MZT embryos. We determine 523 proteins as high confidence RBPs, half of which were not previously reported to bind RNA. Comparison of the RNA interactomes of pre- and post-MZT embryos reveals high dynamicity of the RNA-bound proteome during early development, and suggests active regulation of RNA binding of some RBPs. This resource provides unprecedented insight into the system of RBPs that govern the earliest steps of Drosophila development.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: European Molecular Biology Laboratory   Notes:© 2016 the Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License.

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website: http://www.nature.com/

Journal: Nature Communicationssee more from them

Publication Website: http://www.nature.com/ncomms/index.html

Issue Date: 2016-07-05Identifiers

Urn: uuid:af68a8d7-57e4-4c6e-b3b6-c312830f8574

Source identifier: 625270

Doi: https://doi.org/10.1038/ncomms12128

Issn: 2041-1723 Item Description

Type: Journal article;

Version: Publisher's version Tiny URL: pubs:625270

Relationships





Autor: Castello Palomares, A - institutionUniversity of Oxford Oxford, MSD, Biochemistry grantNumberMR-L019434-1 fundingMedical Research

Fuente: https://ora.ox.ac.uk/objects/uuid:af68a8d7-57e4-4c6e-b3b6-c312830f8574



DESCARGAR PDF




Documentos relacionados