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Reference: Claridge, TDW, Moloney, M, Odell, B et al., (2016). Scalar cross-relaxation detected in the NOESY spectra of oxazolidines and thiazolidines. Journal of Organic Chemistry, 81 (10), 4142–4148.Citable link to this page:

 

Scalar cross-relaxation detected in the NOESY spectra of oxazolidines and thiazolidines

Abstract: Anomalous cross-peaks observed in the NOESY spectra of 2,4-disubstituted thiazolidines and oxazoli-dines that cannot be attributed to classical dipolar NOE or chemical exchange peaks have been investi-gated experimentally and computationally and shown to arise from scalar cross-relaxation of the first kind (SCRFK). This process is stimulated by the relatively slow modulation of scalar couplings, and for the systems studied arises from slow on-off proton exchange of the amino nitrogen, a process influenced by solution temperature, acidity and concentration. The mechanism is likely to be significant for many systems in which proton exchange occurs on the millisecond timescale, and misinterpretation of these cross-peaks may lead to erroneous conclusions should their true origins not be recognised.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: European Research Council   Funder: Medical Research Council   Notes:Copyright © 2016 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.

Bibliographic Details

Publisher: American Chemical Society

Publisher Website: http://pubs.acs.org/

Journal: Journal of Organic Chemistrysee more from them

Publication Website: http://pubs.acs.org/journal/joceah

Volume: 81

Issue: 10

Extent: 4142–4148

Issue Date: 2016-05

Article Number:

pages:4142–4148Identifiers

Urn: uuid:be459b44-40b7-4e00-aca7-5acb64d3c79d

Source identifier: 619466

Doi: https://doi.org/10.1021/acs.joc.6b00458

Issn: 1520-6904 Item Description

Type: Journal article;

Version: Publisher's versionKeywords: thiazolidines oxazolidines NMR NOESY scalar cross-relaxation Tiny URL: pubs:619466

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Autor: Claridge, TDW - institutionUniversity of Oxford Oxford, MPLS, Chemistry, Organic Chemistry - - - Moloney, M - institutionUniversi

Fuente: https://ora.ox.ac.uk/objects/uuid:be459b44-40b7-4e00-aca7-5acb64d3c79d



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