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Reference: Longley, RJ, Hill, AV and Spencer, AJ, (2015). Malaria vaccines: identifying Plasmodium falciparum liver-stage targets. Frontiers in microbiology, 6 (SEP), 965.Citable link to this page:


Malaria vaccines: identifying Plasmodium falciparum liver-stage targets

Abstract: The development of a highly efficacious and durable vaccine for malaria remains a top priority for global health researchers. Despite the huge rise in recognition of malaria as a global health problem and the concurrent rise in funding over the past 10-15 years, malaria continues to remain a widespread burden. The evidence of increasing resistance to anti-malarial drugs and insecticides is a growing concern. Hence, an efficacious and durable preventative vaccine for malaria is urgently needed. Vaccines are one of the most cost-effective tools and have successfully been used in the prevention and control of many diseases, however, the development of a vaccine for the Plasmodium parasite has proved difficult. Given the early success of whole sporozoite mosquito-bite delivered vaccination strategies, we know that a vaccine for malaria is an achievable goal, with sub-unit vaccines holding great promise as they are simple and cheap to both manufacture and deploy. However a major difficulty in development of sub-unit vaccines lies within choosing the appropriate antigenic target from the 5000 or so genes expressed by the parasite. Given the liver-stage of malaria represents a bottle-neck in the parasite's life cycle, there is widespread agreement that a multi-component sub-unit malaria vaccine should preferably contain a liver-stage target. In this article we review progress in identifying and screening Plasmodium falciparum liver-stage targets for use in a malaria vaccine.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher versionNotes:Copyright 2015 Longley, Hill and Spencer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Bibliographic Details

Publisher: Frontiers

Publisher Website:

Journal: Frontiers in microbiologysee more from them

Publication Website:

Issue Date: 2015

Article Number:ARTN 965


Urn: uuid:c25c4c82-f387-4f83-9440-c261cd34a8cb

Source identifier: 570852

Eissn: 1664-302X


Issn: 1664-302X Item Description

Type: Journal article;

Language: eng

Version: Publisher versionKeywords: T cells immunity liver-stage malaria vaccine Tiny URL: pubs:570852


Autor: Longley, RJ - institutionUniversity of Oxford Oxford, MSD, NDM, Jenner Institute fundingRhodes Trust fundingNuffield Department o



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