The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam.Reportar como inadecuado




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Reference: Tran, CB, Nguyen, HT, Phan, HT et al., (2011). The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam. PloS one, 6 (7), Article: e21116.Citable link to this page:

 

The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam.

Abstract: Enterovirus 71 (EV71)-associated hand, foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade. To better understand the prevalence of EV71 infection, we determined EV71 seroprevalence and seroincidence amongst healthy infants and children in Ho Chi Minh City, Viet Nam. In a cohort of 200 newborns, 55% of cord blood samples contained EV71 neutralizing antibodies and these decayed to undetectable levels by 6 months of age in 98% of infants. The EV71 neutralizing antibody seroconversion rate was 5.6% in the first year and 14% in the second year of life. In children 5-15 yrs of age, seroprevalence of EV71 neutralizing antibodies was 84% and in cord blood it was 55%. Taken together, these data suggest EV71 force of infection is high and highlights the need for more research into its epidemiology and pathogenesis in high disease burden countries.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Wellcome Trust   Notes:Copyright 2011 Tran et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Bibliographic Details

Publisher: Public Library of Science

Publisher Website: http://www.plos.org

Journal: PloS onesee more from them

Publication Website: http://www.plosone.org

Issue Date: 2011

pages:Article: e21116Identifiers

Urn: uuid:cd0420eb-7a9e-4a19-8815-356692f32b03

Source identifier: 166443

Eissn: 1932-6203

Doi: https://doi.org/10.1371/journal.pone.0021116

Issn: 1932-6203 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Humans Fetal Blood Enterovirus A, Human Enterovirus Infections Hand, Foot and Mouth Disease Incidence Seroepidemiologic Studies Adolescent Adult Child Infant Antibodies, Neutralizing Antibodies, Viral Immunoglobulins, Intravenous Young Adult Cross-Sectional Studies Vietnam Tiny URL: pubs:166443

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Autor: Tran, CB - - - Nguyen, HT - - - Phan, HT - - - Tran, NV - institutionUniversity of Oxford - - - Wills, B - institutionUniversity

Fuente: https://ora.ox.ac.uk/objects/uuid:cd0420eb-7a9e-4a19-8815-356692f32b03



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