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Reference: Palmer, ND, McDonough, CW, Hicks, PJ et al., (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PloS one, 7 (1), Article: e29202.Citable link to this page:

 

A genome-wide association search for type 2 diabetes genes in African Americans.

Abstract: African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n=550 independent loci) were genotyped in a replication cohort and 122 SNPs (n=98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P



Autor: Palmer, ND - - - McDonough, CW - - - Hicks, PJ - - - Roh, BH - - - Wing, MR - - - An, SS - - - Hester, JM - - - Cooke, JN - - - B

Fuente: https://ora.ox.ac.uk/objects/uuid:d2ac5e39-ffb6-4d76-b93f-ff4690682998



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