Delineating nonmotor symptoms in early Parkinson's disease and first-degree relatives.Reportar como inadecuado




Delineating nonmotor symptoms in early Parkinson's disease and first-degree relatives. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Reference: Baig, F, Lawton, M, Rolinski, M et al., (2015). Delineating nonmotor symptoms in early Parkinson's disease and first-degree relatives. Movement Disorders : official journal of the Movement Disorder Society, 30 (13), 1759–1766.Citable link to this page:

 

Delineating nonmotor symptoms in early Parkinson's disease and first-degree relatives.

Abstract: Nonmotor symptoms (NMS) are an important prodromal feature of Parkinson's disease (PD). However, their frequency, treatment rates, and impact on health-related quality of life (HRQoL) in the early motor phase is unclear. Rates of NMS in enriched at-risk populations, such as first-degree PD relatives, have not been delineated. We assessed NMS in an early cohort of PD, first-degree PD relatives and control subjects to address these questions. In total, 769 population-ascertained PD subjects within 3.5 years of diagnosis, 98 first-degree PD relatives, and 287 control subjects were assessed at baseline across the following NMS domains: (1) neuropsychiatric; (2) gastrointestinal; (3) sleep; (4) sensory; (5) autonomic; and (6) sexual. NMS were much more common in PD, compared to control subjects. More than half of the PD cases had hyposmia, pain, fatigue, sleep disturbance, or urinary dysfunction. NMS were more frequent in those with the postural instability gait difficulty phenotype, compared to the tremor dominant (mean total number of NMS 7.8 vs. 6.2; P 



Autor: Baig, F - institutionUniversity of Oxford Oxford, MSD, Clinical Neurosciences - - - Lawton, M - - - Rolinski, M - institutionUniv

Fuente: https://ora.ox.ac.uk/objects/uuid:d2abba9d-bc01-45c1-982d-de1916d8d049



DESCARGAR PDF




Documentos relacionados