Hand, foot, and mouth disease in China: Modeling epidemic dynamics of enterovirus serotypes and implications for vaccination.Report as inadecuate

Hand, foot, and mouth disease in China: Modeling epidemic dynamics of enterovirus serotypes and implications for vaccination. - Download this document for free, or read online. Document in PDF available to download.

Reference: Takahashi, S, Liao, Q, Van Boeckel, TP et al., (YYYY-MM-DD). Hand, foot, and mouth disease in China: Modeling epidemic dynamics of enterovirus serotypes and implications for vaccination. PLoS medicine, 13 (2), e1001958.Citable link to this page:


Hand, foot, and mouth disease in China: Modeling epidemic dynamics of enterovirus serotypes and implications for vaccination.

Abstract: BackgroundHand, foot, and mouth disease (HFMD) is a common childhood illness caused by serotypes of the Enterovirus Aspecies in the genus Enterovirus of the Picornaviridae family. The disease has had a substantial burden throughout East and Southeast Asia over the past 15 y. China reported 9 million cases of HFMD between 2008 and 2013, with the two serotypes Enterovirus A71 (EV-A71) and Coxsackievirus A16 (CV-A16) being responsible for the majority of these cases. Three recent phase 3 clinical trials showed that inactivated monovalent EV-A71 vaccines manufactured in China were highly efficacious against HFMD associated with EV-A71, but offered no protection against HFMD caused by CV-A16. To better inform vaccination policy, we used mathematical models to evaluate the effect of prospective vaccination against EV-A71-associated HFMD and the potential risk of serotype replacement by CV-A16. We also extended the model to address the co-circulation, and implications for vaccination, of additional non-EV-A71, non-CV-A16 serotypes of enterovirus.Methods and FindingsWeekly reports of HFMD incidence from 31 provinces in Mainland China from 1 January 2009 to 31 December 2013 were used to fit multi-serotype time series susceptible–infected–recovered (TSIR) epidemic models. We obtained good model fit for the two-serotype TSIR with cross-protection, capturing the seasonality and geographic heterogeneity of province-level transmission, with strong correlation between the observed and simulated epidemic series. The national estimate of the basic reproduction number,R0, weighted by provincial population size, was 26.63 for EV-A71 (interquartile range [IQR]: 23.14, 30.40) and 27.13 for CV-A16 (IQR: 23.15, 31.34), with considerable variation between provinces (however, predictions about the overall impact of vaccination were robust to this variation). EV-A71 incidence was projected to decrease monotonically with higher coverage rates of EV-A71 vaccination. Across provinces, CV-A16 incidence in the post-EV-A71-vaccination period remained either comparable to or only slightly increased from levels prior to vaccination. The duration and strength of cross-protection following infection with EV-A71 or CV-A16 was estimated to be 9.95 wk (95% confidence interval [CI]: 3.31, 23.40) in 68% of the population (95% CI: 37%, 96%). Our predictions are limited by the necessarily short and under-sampled time series and the possible circulation of unidentified serotypes, but, nonetheless, sensitivity analyses indicate that our results are robust in predicting that the vaccine should drastically reduce incidence of EV-A71 without a substantial competitive release of CV-A16.ConclusionsThe ability of our models to capture the observed epidemic cycles suggests that herd immunity is driving the epidemic dynamics caused by the multiple serotypes of enterovirus. Our results predict that the EV-A71 and CV-A16 serotypes provide a temporary immunizing effect against each other. Achieving high coverage rates of EV-A71 vaccination would be necessary to eliminate the ongoing transmission of EV-A71, but serotype replacement by CV-A16 following EV-A71 vaccination is likely to be transient and minor compared to the corresponding reduction in the burden of EV-A71-associated HFMD. Therefore, a mass EV-A71 vaccination program of infants and young children should provide significant benefits in terms of a reduction in overall HFMD burden.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: National Science Fund for Distinguished Young Scholars   Funder: National Natural Science Foundation of China   Funder: Li Ka Shing Oxford Global Health Programme   Funder: Department of Homeland Security   Funder: Fulbright Program   Funder: Bill and Melinda Gates Foundation   Funder: National Institutes of Health   Funder: National Institute of General Medical Sciences   Funder: Government of the Hong Kong Special Administrative Region   Funder: Wellcome Trust   Funder: Li Ka Shing Oxford Global Health Programme   Notes:© 2016 Takahashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Bibliographic Details

Publisher: Public Library of Science

Publisher Website: http://www.plos.org/

Journal: PLoS medicinesee more from them

Publication Website: http://journals.plos.org/plosmedicine/

Issue Date: YYYY-MM-DD


Urn: uuid:e0a03c5d-1103-466f-94f0-2bc179edae7f

Source identifier: 605986

Eissn: 1549-1676

Doi: https://doi.org/10.1371/journal.pmed.1001958

Issn: 1549-1277 Item Description

Type: Journal article;

Language: eng

Version: Publisher's version Tiny URL: pubs:605986


Author: Takahashi, S - - - Liao, Q - - - Van Boeckel, TP - - - Xing, W - - - Sun, J - - - Hsiao, VY - - - Metcalf, CJ - - - Chang, Z - -

Source: https://ora.ox.ac.uk/objects/uuid:e0a03c5d-1103-466f-94f0-2bc179edae7f


Related documents