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Reference: Brittain, JS, Watkins, KE, Joundi, RA et al., (2012). A role for the subthalamic nucleus in response inhibition during conflict. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32 (39), 13396-13401.Citable link to this page:

 

A role for the subthalamic nucleus in response inhibition during conflict.

Abstract: The subthalamic nucleus (STN) is a key node in the network that supports response inhibition. It is suggested that the STN rapidly inhibits basal ganglia activity, to pause motor output during conflict until an appropriate motor plan is ready. Here, we recorded neural activity during a Stroop task from deep brain stimulation electrodes implanted in the human STN. We intended to determine whether cognitive psychological phenomena such as the Stroop effect can be explained via mechanisms of response inhibition involving the STN, or whether higher cognitive centers are alone responsible. We show stimulus-driven desychronization in the beta band (15-35 Hz) that lasts throughout the verbal response, in keeping with the idea that beta-band synchrony decreases to allow motor output to occur. During incongruent trials--in which response times were elongated due to the Stroop effect--a resynchronization was seen in the beta band before response. Crucially, in the incongruent trials during which the participant was unable to withhold the prepotent response, this resynchronization occurred after response onset. We suggest that this beta-band resynchronization pauses the motor system until conflict can be resolved.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Wellcome Trust   Funder: Engineering and Physical Sciences Research Council   Notes:Copyright © 2012 the authors. This article is freely available online through theJ Neurosci Open Choice option.

Bibliographic Details

Publisher: Society for Neuroscience

Publisher Website: http://www.sfn.org/

Journal: The Journal of neuroscience : the official journal of the Society for Neurosciencesee more from them

Publication Website: http://www.jneurosci.org/

Issue Date: 2012-09

pages:13396-13401Identifiers

Urn: uuid:ecd08e68-c4e0-4d0a-b088-defd6f44bd39

Source identifier: 352407

Eissn: 1529-2401

Doi: https://doi.org/10.1523/jneurosci.2259-12.2012

Issn: 0270-6474 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Humans Subthalamic Nucleus Parkinson Disease Magnetic Resonance Imaging Beta Rhythm Spectrum Analysis Deep Brain Stimulation Reaction Time Photic Stimulation Inhibition (Psychology) Evoked Potentials, Visual Neuropsychological Tests Biophysics Conflict (Psychology) Contingent Negative Variation Female Vocabulary Male Tiny URL: pubs:352407

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Autor: Brittain, JS - - - Watkins, KE - institutionUniversity of Oxford Oxford, MSD, RDM, Cardiovascular Medicine - - - Joundi, RA - - -

Fuente: https://ora.ox.ac.uk/objects/uuid:ecd08e68-c4e0-4d0a-b088-defd6f44bd39



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