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Reference: Stepniewska, K, Price, RN, Sutherland, CJ et al., (2008). Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity. Malaria Journal, 7 (1), Article: 249.Citable link to this page:

 

Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicity.

Abstract: BACKGROUND: The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity. METHODS: Retrospective data from Thailand, The Gambia and Tanzania were used. The data came from large prospective field-based clinical trials, which investigated gametocyte carriage after different anti-malarial drug treatments. RESULTS: Gametocytaemia was detected during the observation period in 12% of patients (931 out of 7548) in Thailand, 34% (683 out of 2020) in The Gambia, and 31% (430 out of 1400) in Tanzania (p < 0.001). Approximately one third (33%, 680/2044) of the patients with gametocytaemia during the observation period, already had patent gametocytaemia at enrolment (day 0 or day 1): 35% (318/931) in Thailand, 37% (250/683) in The Gambia, 26% (112/430) in Tanzania. Maximum gametocytaemia was usually observed on or before the seventh day after starting treatment (93% in Thailand, 70% in Tanzania and 78% in The Gambia). Lowest gametocyte carriage rates were observed following treatment with artemisinin derivatives, while sulphadoxine-pyrimethamine (SP) was associated with significantly greater development of gametocytaemia than other drug treatments (p < 0.001). The duration of gametocyte carriage was shorter in Thailand by 86% and Tanzania by 65% than in The Gambia. Gametocyte carriage was 27% longer among people presenting with anaemia, and was shorter in duration among patients who received artemisinin derivatives, by 27% in Thailand and by 71% in Tanzania and The Gambia. CONCLUSION: This study confirms the independent association of gametocytaemia with anaemia, and the significantly lower prevalence and duration of gametocyte carriage following treatment with an artemisinin derivative. The large differences in gametocyte carriage rates between regions with different levels of malaria transmission suggest that drug interventions to prevent transmission will have different effects in different places.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Directorate General of Development Cooperation of the Dutch Ministry of Foreign Affairs   Notes:© 2008 Stepniewska et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: BioMed Central Ltd.

Publisher Website: http://www.biomedcentral.com/

Journal: Malaria Journalsee more from them

Publication Website: http://www.malariajournal.com/

Issue Date: 2008

pages:Article: 249Identifiers

Urn: uuid:f5212236-d877-4ea6-80a8-cbfb961b8de1

Source identifier: 25375

Eissn: 1475-2875

Doi: https://doi.org/10.1186/1475-2875-7-249

Issn: 1475-2875 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Animals Humans Plasmodium falciparum Parasitemia Malaria, Falciparum Sulfadoxine Drug Combinations Multivariate Analysis Proportional Hazards Models Retrospective Studies Artemisinins Adolescent Child Child, Preschool Infant, Newborn Infant Antimalarials Carrier State Kaplan-Meier Estimate Endemic Diseases Pyrimethamine Tanzania Thailand Female Gambia Male Tiny URL: pubs:25375

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Autor: Stepniewska, K - institutionUniversity of Oxford - - - Price, RN - - - Sutherland, CJ - - - Drakeley, CJ - - - von Seidlein, L -

Fuente: https://ora.ox.ac.uk/objects/uuid:f5212236-d877-4ea6-80a8-cbfb961b8de1



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