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Reference: Yeh Chen Lee, Dominic F. Kelly, Ly-Mee Yu et al., (2008). Haemophilus influenzae Type b vaccine failure in children is associated with inadequate production of high-quality antibody. Clinical Infectious Diseases, 46 (2), 186-192.Citable link to this page:

 

Haemophilus influenzae Type b vaccine failure in children is associated with inadequate production of high-quality antibody

Abstract: Background: Despite the excellent immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines, breakthrough cases of Hib disease still affect a small proportion of vaccinated children in the United Kingdom. We performed a retrospective study to compare the avidity of antibody directed against the Hib polysaccharide capsule (PRP) in children who experienced Hib vaccine failure in the United Kingdom among 3 historical cohorts and with age-matched healthy control subjects.Methods: Serum samples from vaccinated children with invasive Hib disease were collected beginning in 1992 as part of enhanced surveillance for Hib disease following vaccine introduction. A total of 251 children who experienced Hib vaccine failure were identified from 3 historical cohorts (1992-1995, 1996-1999, and 2000-2003). The anti-PRP antibody concentration and avidity from healthy age-matched control subjects was obtained for the 3 contemporary time points (1995, 1999, and 2002). Serum anti-PRP antibody concentration was measured in each of the samples using a standard Hib ELISA, and antibody avidity was determined using thiocyanate elution.Results. Within the first 60 days after disease onset, there was no change in the anti-PRP antibody avidity, and there was no statistically significant difference in the geometric mean Hib antibody avidity over the 3 study periods. However, the children who experienced Hib vaccine failure had significantly lower Hib antibody avidity than did healthy control subjects, despite a marked antibody response following infection.Conclusions. Children who experience Hib disease despite vaccination appear to have a defect in immunological priming, leading to a qualitative difference in Hib-specific memory B cells. Low anti-PRP antibody avidity decreases the functional activity of anti-PRP antibody in the sera of these children experiencing vaccine failure, leading to disease susceptibility.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionNotes:Citation: Lee, Y. C. et al. (2008). 'Haemophilus influenzae Type b vaccine failure in children is associated with inadequate production of high-quality antibody', Clinical Infectious Diseases, 46(2), 186-192. [Available at http://www.journals.uchicago.edu/toc/cid/current].

Bibliographic Details

Publisher: University of Chicago Press

Publisher Website: http://www.journals.uchicago.edu/

Host: Clinical Infectious Diseasessee more from them

Publication Website: http://www.journals.uchicago.edu/toc/cid/current

Issue Date: 2008-January

Copyright Date: 2007

pages:186-192Identifiers

Doi: https://doi.org/10.1086/524668

Issn: 1058-4838

Urn: uuid:f709ac94-1c79-45aa-af48-47f0a372727a Item Description

Type: Article: post-print;

Language: en

Version: Publisher's versionKeywords: Haemophilus influenzae type b (Hib) vaccineSubjects: Paediatrics Statistics (see also social sciences) Infectious diseases Vaccinology Tiny URL: ora:3048

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Author: Yeh Chen Lee - institutionUniversity of Oxford facultyMedical Sciences Division - Paediatrics,Department of - - - Dominic F. Kell

Source: https://ora.ox.ac.uk/objects/uuid:f709ac94-1c79-45aa-af48-47f0a372727a



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