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Reference: Laine, VN, Gossmann, TI, Schachtschneider, KM et al., (2016). Evolutionary signals of selection on cognition from the great tit genome and methylome. Nature communications, 7, 10474.Citable link to this page:

 

Evolutionary signals of selection on cognition from the great tit genome and methylome.

Abstract: For over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemble a great tit reference genome and whole-genome re-sequence another 29 individuals from across Europe. We show an overrepresentation of genes related to neuronal functions, learning and cognition in regions under positive selection, as well as increased CpG methylation in these regions. In addition, great tit neuronal non-CpG methylation patterns are very similar to those observed in mammals, suggesting a universal role in neuronal epigenetic regulation which can affect learning-, memory- and experience-induced plasticity. The high-quality great tit genome assembly will play an instrumental role in furthering the integration of ecological, evolutionary, behavioural and genomic approaches in this model species.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website: http://www.nature.com/

Journal: Nature communicationssee more from them

Publication Website: http://www.nature.com/ncomms/

Issue Date: 2016

pages:10474Identifiers

Urn: uuid:fb51de90-4634-404a-b8b0-2b9f8e47a422

Source identifier: 598107

Eissn: 2041-1723

Doi: https://doi.org/10.1038/ncomms10474 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Great Tit HapMap Consortium Tiny URL: pubs:598107

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Author: Laine, VN - - - Gossmann, TI - - - Schachtschneider, KM - - - Garroway, CJ - - - Madsen, O - - - Verhoeven, KJ - - - de Jager, V

Source: https://ora.ox.ac.uk/objects/uuid:fb51de90-4634-404a-b8b0-2b9f8e47a422



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