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Reference: Rachlin, A, Dittrich, S, Phommasone, K et al., (2016). Investigation of recurrent melioidosis in Lao People's Democratic Republic by multilocus sequence typing. American Journal of Tropical Medicine and Hygiene.Citable link to this page:

 

Investigation of recurrent melioidosis in Lao People's Democratic Republic by multilocus sequence typing

Abstract: Melioidosis is an infectious disease caused by the saprophytic bacterium Burkholderia pseudomallei. In northeast Thailand and northern Australia, where the disease is highly endemic, a range of molecular tools have been used to study its epidemiology and pathogenesis. In the Lao People's Democratic Republic (Laos) where melioidosis has been recognized as endemic since 1999, no such studies have been undertaken. We used a multilocus sequence typing scheme specific for B. pseudomallei to investigate nine cases of culture-positive recurrence occurring in 514 patients with melioidosis between 2010 and 2015: four were suspected to be relapses while the other five represented reinfections. In addition, two novel sequence types of the bacterium were identified. The low overall recurrence rates (2.4%) and proportions of relapse and reinfection in the Laos are consistent with those described in the recent literature, reflecting the effective use of appropriate antimicrobial therapy.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Accepted Manuscript Funder: Wellcome Trust   Funder: London School ofHygiene and Tropical Medicine   Notes:Copyright © The American Society of Tropical Medicine and HygieneThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Bibliographic Details

Publisher: American Society of Tropical Medicine and Hygiene

Publisher Website: http://www.astmh.org/

Journal: American Journal of Tropical Medicine and Hygienesee more from them

Publication Website: http://www.ajtmh.org/

Issue Date: 2016Identifiers

Urn: uuid:fa000f1d-83ff-46ca-b052-97079301d4b1

Source identifier: 611922

Eissn: 1476-1645

Doi: https://doi.org/10.4269/ajtmh.15-0909 Item Description

Type: Journal article;

Language: ENG

Version: Accepted Manuscript Tiny URL: pubs:611922

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Author: Rachlin, A - - - Dittrich, S - - - Phommasone, K - - - Douangnouvong, A - - - Phetsouvanh, R - - - Newton, PN - - - Dance, DA - i

Source: https://ora.ox.ac.uk/objects/uuid:fa000f1d-83ff-46ca-b052-97079301d4b1



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