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Reference: Ramagopalan, SV, Seminog, O, Goldacre, R et al., (2012). Risk of fractures in patients with multiple sclerosis: record-linkage study. BMC neurology, 12 (1), 135.Citable link to this page:


Risk of fractures in patients with multiple sclerosis: record-linkage study.

Abstract: BACKGROUND: Patients with multiple sclerosis (MS) have been reported to be at higher risk of fracture than other people. We sought to test this hypothesis in a large database of hospital admissions in England. METHODS: We analysed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999-2010). Rate ratios for fractures were determined, comparing fracture rates in a cohort of all people in England admitted with MS and rates in a comparison cohort. RESULTS: Significantly elevated risk for all fractures was found in patients with MS (rate ratio (RR) = 1.99, 95% confidence interval (CI) = 1.93-2.05)). Risks were particularly high for femoral fractures (femoral neck fracture RR = 2.79 (2.65-2.93); femoral shaft fracture RR 6.69 (6.12-7.29)), and fractures of the tibia or ankle RR = 2.81 (2.66-2.96). CONCLUSIONS: Patients with MS have an increased risk of fractures. Caregivers should aim to optimize bone health in MS patients.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: National Institute for Health Research   Notes:© 2012 Ramagopalan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Bibliographic Details

Publisher: BioMed Central Ltd.

Publisher Website: http://www.biomedcentral.com/

Journal: BMC neurologysee more from them

Publication Website: http://www.biomedcentral.com/bmcneurol/

Issue Date: 2012


Urn: uuid:f8fcb452-f925-4cec-91ea-0a47447d48b3

Source identifier: 358461

Eissn: 1471-2377

Doi: https://doi.org/10.1186/1471-2377-12-135

Issn: 1471-2377 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Multiple sclerosis Fractures Epidemiology Adolescent Adult Aged Aged, 80 and over Databases, Factual England Female Fractures, Bone Hospitalization Humans Male Medical Record Linkage Middle Aged Multiple Sclerosis RiskSubjects: Multiple Sclerosis Orthopaedics Tiny URL: pubs:358461


Author: Ramagopalan, SV - institutionUniversity of Oxford Oxford, MSD, Physiology Anatomy and Genetics - - - Seminog, O - institutionUniv

Source: https://ora.ox.ac.uk/objects/uuid:f8fcb452-f925-4cec-91ea-0a47447d48b3


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