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Reference: Wilkinson, DJ, Barnett, C, Savulescu, J et al., (2015). Genomic intensive care: should we perform genome testing in critically ill newborns?. Archives of disease in childhood. Fetal and neonatal edition, fetalneonatal-2015-308568-fetalneonatal-2015-308568.Citable link to this page:

 

Genomic intensive care: should we perform genome testing in critically ill newborns?

Abstract: In newborn intensive care units (NICUs), the science and art of prognostication often have life and death implications. Approximately 5% of infants admitted to NICU die.1 The majority of deaths are preceded by decisions to withdraw or withhold life-sustaining treatment,1 following discussions between the family and clinical team. These decisions are based on an assessment of an infant's chance of survival and on the predicted duration and nature of the infant's survival if treatment is provided.2A variety of clinical, biochemical, genetic and radiological tests have traditionally been employed to estimate prognosis in the NICU. While chromosomal microarray is now commonly used for critically ill neonates with congenital malformations, new forms of genetic and genomic testing3 have started to become available in intensive care.4 They could aid critical care decision-making by predicting functional outcome, important comorbidities5 or poor prognosis despite treatment4 (box 1).

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's versionNotes:Copyright Article author (or their employer) 2015. Produced by BMJ Publishing Group Ltd (and RCPCH) under licence. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license. This is the publisher's version of the article. The final version is available online from BMJ at: [10.1136/archdischild-2015-308568]

Bibliographic Details

Publisher: BMJ Publishing Group

Publisher Website: http://group.bmj.com/

Journal: Archives of disease in childhood. Fetal and neonatal editionsee more from them

Publication Website: http://fn.bmj.com/

Issue Date: 2015-09-14

pages:fetalneonatal-2015-308568-fetalneonatal-2015-308568Identifiers

Urn: uuid:fca7da90-fb9e-46f4-a0ac-544096dc2793

Source identifier: 588962

Eissn: 1468-2052

Doi: https://doi.org/10.1136/archdischild-2015-308568

Issn: 1359-2998 Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: Ethics Genetics Intensive Care Neonatology Tiny URL: pubs:588962

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Author: Wilkinson, DJ - institutionUniversity of Oxford Oxford, HUM, Philosophy Faculty grantNumber1016641 grantNumber086041-Z-08-Z fundi

Source: https://ora.ox.ac.uk/objects/uuid:fca7da90-fb9e-46f4-a0ac-544096dc2793



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