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Reference: Van Wilgenburg, B, Klenerman, P, Willberg, C et al., (2016). MAIT cells are activated during human viral infections. Nature Communications.Citable link to this page:


MAIT cells are activated during human viral infections

Abstract: Mucosal Associated Invariant T (MAIT) cells are abundant in humans and recognise bacterial ligands. Here we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with Dengue virus, Hepatitis C virus, and Influenza Virus. This activation – driving cytokine release and Granzyme B upregulation - is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute Dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR- independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: National Institutes for Health Research   Funder: Wellcome Trust   Funder: Medical Research Council   Notes:© the Authors. TThis work is licensed under a Creative Commons Attribution 4.0International License.

Bibliographic Details

Publisher: Nature Publishing Group

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Journal: Nature Communicationssee more from them

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Issue Date: 2016-06-23Identifiers

Urn: uuid:fa2e35c1-9991-4207-a98c-ea10e7b08b8f

Source identifier: 617901


Issn: 2041-1723 Item Description

Type: Journal article;

Version: Publisher's version Tiny URL: pubs:617901


Author: Van Wilgenburg, B - institutionUniversity of Oxford Oxford, MSD, NDM, NDM Experimental Medicine - - - Klenerman, P - institutionU



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