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Reference: te Velthuis, AJW, (2014). Common and unique features of viral RNA-dependent polymerases. Cellular and Molecular Life Sciences, 71 (22), 4403-4420.Citable link to this page:


Common and unique features of viral RNA-dependent polymerases.

Abstract: Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies. Nevertheless, the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates. This review provides an overview of our current understanding of the viral RNA-dependent polymerase structure and the biochemistry and biophysics that is involved in replicating and transcribing the genetic material of RNA viruses.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Publisher's version Funder: Netherlands Organization for Scientific Research   Funder: Wellcome Trust   Funder: Lincoln College Oxford   Notes:© The Author(s) 2014. This article is published with open access at This is the publisher's version of the article. The final version is available online from Springer Verlag at: [10.1007/s00018-014-1695-z].

Bibliographic Details

Publisher: Springer Verlag

Publisher Website:

Journal: Cellular and Molecular Life Sciencessee more from them

Publication Website:

Issue Date: 2014-08-1


Urn: uuid:ffc8eceb-6310-46db-a2e3-cd932c9121f2

Source identifier: 572152

Eissn: 1420-9071


Issn: 1420-682X Item Description

Type: Journal article;

Language: eng

Version: Publisher's versionKeywords: RNA Viruses DNA-Directed RNA Polymerases RNA, Viral Catalytic Domain Promoter Regions, Genetic Protein Multimerization Tiny URL: pubs:572152


Autor: te Velthuis, AJW - institutionUniversity of Oxford Oxford, MSD, Pathology Dunn School - - - - Bibliographic Details Publisher: Sp



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