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Reference: Jacobs, A, Mongkolsapaya, J, Screaton, GR et al., (201). Antibodies and tuberculosis. Tuberculosis, 101, 102-113.Citable link to this page:

 

Antibodies and tuberculosis

Abstract: Tuberculosis (TB) remains a major public health problem internationally, causing 9.6 million new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine is the only licensed vaccine against TB, but its protective effect does not extend to controlling the development of infectious pulmonary disease in adults. The development of a more effective vaccine against TB is therefore a pressing need for global health. Although it is established that cell-mediated immunity is necessary for the control of latent infection, the presupposition that such immunity is sufficient for vaccine-induced protection has recently been challenged. A greater understanding of protective immunity against TB is required to guide future vaccine strategies against TB. In contrast to cell-mediated immunity, the human antibody response against M.tb is conventionally thought to exert little immune control over the course of infection. Humoral responses are prominent during active TB disease, and have even been postulated to contribute to immunopathology. However, there is evidence to suggest that specific antibodies may limit the dissemination of M.tb, and potentially also play a role in prevention of infection via mucosal immunity. Further, antibodies are now understood to confer protection against a range of intracellular pathogens by modulating immunity via Fc-receptor mediated phagocytosis. In this review, we will explore the evidence that antibody-mediated immunity could be reconsidered in the search for new vaccine strategies against TB.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's VersionDate of acceptance:2016-08-04Notes:© 2016 The Authors. Published by Elsevier. This is the an Open Access article published under a Creative Commons License. For more information, see: https://creativecommons.org/licenses/by/4.0/

Bibliographic Details

Publisher: Elsevier

Publisher Website: https://www.elsevier.com/

Journal: Tuberculosissee more from them

Publication Website: http://www.journals.elsevier.com/tuberculosis/

Volume: 101

Issue Date: 201-12-01

pages:102-113Identifiers

Doi: https://doi.org/10.1016/j.tube.2016.08.001

Issn: 1472-9792

Eissn: 1873-281X

Uuid: uuid:d38ae341-6509-4ad7-a361-18a11f8fd247

Urn: uri:d38ae341-6509-4ad7-a361-18a11f8fd247

Pubs-id: pubs:648020 Item Description

Type: journal-article;

Version: Publisher's VersionKeywords: tuberculosis antibodies humoral immunity vaccine

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Autor: Jacobs, A - - - Mongkolsapaya, J - - - Screaton, GR - - - McShane, H - facultyOxford, MSD, NDM, Jenner Institute - - - Wilkinson,

Fuente: https://ora.ox.ac.uk/objects/uuid:d38ae341-6509-4ad7-a361-18a11f8fd247



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