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Reference: Sharpley, AL, Cooper, CM, Williams, C et al., (2016). Effects of typhoid vaccine on inflammation and sleep in healthy participants: a double-blind, placebo-controlled, crossover study. Psychopharmacology, 233 (18), 3429-3435.Citable link to this page:

 

Effects of typhoid vaccine on inflammation and sleep in healthy participants: a double-blind, placebo-controlled, crossover study.

Abstract: RationaleAn increasing body of evidence links the occurrence of sleep continuity disturbances with increased inflammation and both sleep disturbances and inflammation are associated with clinical depression. Typhoid vaccination results in a mild inflammatory response that significantly increases levels of the proinflammatory cytokine, interleukin (IL)-6.ObjectivesThe present exploratory study aimed to enhance our understanding of the link between inflammation, sleep and depression by examining the effects of typhoid vaccine on the sleep polysomnogram.MethodsWe studied the effects of a single injection of typhoid polysaccharide vaccine and placebo (saline solution) on sleep in 16 healthy male and female participants aged 20–38 years, sleeping at home in a randomized, double-blind, balanced order, crossover design. Subjective measures of mood, sleep and adverse effects were elicited and plasma samples analysed for IL-6 levelsResultsL-6 levels (in picogramme per millilitre) significantly increased 2 h post vaccine compared to placebo (0.90 vs 0.53,p=0.026,r= 0.55). Relative to placebo, typhoid vaccination produced significant impairment in several measures of sleep continuity. Total sleep time (in minute) (426.1 vs 410.7,p= 0.005,r = 0.62) and sleep efficiency percent (94.3 vs 91.5, p= 0.007,r = 0.65) were decreased; with increases in wake after sleep onset (in minute) (25.5 vs 38.8, p= 0.007,r= 0.65), total wake (in minute) (34.9 vs 50.3, p=0.005,r= 0.67), sleep stage transitions (155.9 vs 173.1, p=0.026,r= 0.56), number of awakenings (27.2 vs 36.1, p= 0.007,r = 0.64) and awakening index (3.8 vs 5.3, p=0.005,r= 0.67) (means, significance level and effect size). ConclusionsInflammatory mechanisms may underlie the impairment in sleep efficiency which is a hallmark of major depression. Because impaired sleep is also a predictor of major depression, there may be a role for suitable anti-inflammatory approaches in strategies designed to prevent the onset of depression.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2016-07-09 Funder: Oxford University Departmental funds   Notes:© The Author(s) 2016. This article is published with open access at Springerlink.com This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproductionin any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Bibliographic Details

Publisher: Springer

Publisher Website: http://www.springer.com/

Journal: Psychopharmacologysee more from them

Publication Website: http://link.springer.com/journal/213

Volume: 233

Issue: 18

Extent: 3429-3435

Issue Date: 2016-08

pages:3429-3435Identifiers

Doi: https://doi.org/10.1007/s00213-016-4381-z

Issn: 1432-2072

Issn: 0033-3158

Uuid: uuid:68914d2a-6848-4495-95a7-967f358a2f98

Urn: uri:68914d2a-6848-4495-95a7-967f358a2f98

Pubs-id: pubs:638231 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: Inflammation Interleukin-6 Typhoid vaccine Sleep continuity disturbances Depression Healthy participants

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Autor: Sharpley, AL - Oxford, MSD, Psychiatry - - - Cooper, CM - Oxford, MSD, Psychiatry - - - Williams, C - Oxford, MSD, Psychiatry - -

Fuente: https://ora.ox.ac.uk/objects/uuid:68914d2a-6848-4495-95a7-967f358a2f98



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