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Reference: Moody, MA, Pedroza-Pacheco, I, Vandergrift, NA et al., (2016). Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies. Science Immunology, 1 (1), Article: aag0851.Citable link to this page:

 

Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies

Abstract: Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1–infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1–infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1–infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death–1 expression compared with HIV-1–infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1–infected individuals.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Accepted ManuscriptDate of acceptance:25 June 2016 Funder: National Institutes of Health   Funder: Medical Research Council   Notes:Copyright © 2016 American Association for the Advancement of Science. This is the accepted manuscript version of the article. The final version is available online from American Association for the Advancement of Science at: http://dx.doi.org/10.1126/sciimmunol.aag0851

Bibliographic Details

Publisher: American Association for the Advancement of Science

Publisher Website: http://www.aaas.org/

Journal: Science Immunologysee more from them

Publication Website: http://immunology.sciencemag.org/

Volume: 1

Issue: 1

Extent: Article: aag0851

Issue Date: 29 July 2016

pages:Article: aag0851Identifiers

Uuid: d6749a0f-e82e-4ea5-81a3-c37d91f714d4

Urn: uri:d6749a0f-e82e-4ea5-81a3-c37d91f714d4

Pubs-id: pubs:638177

Doi: https://doi.org/10.1126/sciimmunol.aag0851

Issn: 2470-9468 Item Description

Type: journal-article;

Version: Accepted Manuscript

Relationships





Autor: Moody, MA - - - Pedroza-Pacheco, I - Oxford, MSD, NDM, Target Discovery Institute - - - Vandergrift, NA - - - Chui, C - - - Lloyd

Fuente: https://ora.ox.ac.uk/objects/uuid:d6749a0f-e82e-4ea5-81a3-c37d91f714d4



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