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Reference: Penman, B, Moffett, A, Chazara, O et al., (2016). Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution. Immunogenetics, 68, 755–764.Citable link to this page:

 

Reproduction, infection and killer-cell immunoglobulin-like receptor haplotype evolution

Abstract: Killer-cell immunoglobulin-like receptors (KIRs) are encoded by one of the most polymorphic families in the human genome. KIRs are expressed on natural killer (NK) cells, which have dual roles: (1) in fighting infection and (2) in reproduction, regulating hemochorial placentation. Uniquely among primates, human KIR genes are arranged into two haplotypic combinations: KIR A and KIR B. It has been proposed that KIR A is specialized to fight infection, whilst KIR B evolved to help ensure successful reproduction. Here we demonstrate that a combination of infectious disease selection and reproductive selection can drive the evolution of KIR B-like haplotypes from a KIR A-like founder haplotype. Continued selection to survive and to reproduce maintains a balance between KIR A and KIR B.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:24 June 2016 Funder: Wellcome Trust   Funder: European Research Council   Notes:Copyright © 2016 The Author(s). s This article is distributed under the terms of the CreativeCommons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,distribution, and reproduction in any medium, provided you giveappropriate credit to the original author(s) and the source, provide a linkto the Creative Commons license, and indicate if changes were made.

Bibliographic Details

Publisher: Springer Berlin Heidelberg

Publisher Website: http://wwww.springer.com/

Journal: Immunogeneticssee more from them

Publication Website: http://link.springer.com/journal/251

Volume: 68

Extent: 755–764

Issue Date: 12 August 2016

pages:755–764Identifiers

Doi: https://doi.org/10.1007/s00251-016-0935-9

Eissn: 1432-1211

Issn: 0093-7711

Uuid: uuid:f70d8c78-df6f-4a2d-9e9f-2af06feeb6b5

Urn: uri:f70d8c78-df6f-4a2d-9e9f-2af06feeb6b5

Pubs-id: pubs:634664 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: human evolution infectious disease killer-cell immunoglobulin-like receptors (KIRs) natural killer cells reproduction

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Autor: Penman, B - Oxford, MPLS, Zoology - - - Moffett, A - - - Chazara, O - - - Gupta, S - Oxford, MPLS, Zoology - - - Parham, P - - -

Fuente: https://ora.ox.ac.uk/objects/uuid:f70d8c78-df6f-4a2d-9e9f-2af06feeb6b5



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