RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.Reportar como inadecuado




RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Reference: Rose, Nathan R., King, Hamish W., Blackledge, Neil P. et al., (2016). RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. eLife.Citable link to this page:

 

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.

Abstract: Polycomb group (PcG) proteins function as chromatin-based transcriptional repressors that are essential for normal gene regulation during development. However, how these systems function to achieve transcriptional regulation remains very poorly understood. Here, we discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1(PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation. In mouse embryonic stem cells, RYBP plays a central role in shaping H2AK119 mono-ubiquitylation at PcG targets and underpins an activity-based communication between PRC1 and Polycomb repressive complex 2(PRC2) which is required for normal histone H3 lysine 27 trimethylation(H3K27me3). Without normal histone modification-dependent communication between PRC1 and PRC2, repressive Polycomb chromatin domains can erode, rendering target genes susceptible to inappropriate gene expression signals. This suggests that activity-based communication and histone modification-dependent thresholds create a localized form of epigenetic memory required for normal PcG chromatin domain function in gene regulation.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's VersionDate of acceptance:2016-10-01Notes:© 2016, Rose et al. Published by eLife Sciences Publications. This article is distributed under the terms of the Creative Commons Attribution License 4.0 permitting unrestricted use and redistribution provided that the original author and source are credited, see: https://creativecommons.org/licenses/by/4.0/

Bibliographic Details

Publisher: eLife Sciences Publications

Publisher Website: https://elifesciences.org/

Journal: eLifesee more from them

Publication Website: https://elifesciences.org/

Volume: 5

Issue Date: 05 October 2016Identifiers

Doi: https://doi.org/10.7554/eLife.18591

Eissn: 2050-084X

Uuid: uuid:34ba0527-dfd1-42aa-9f2c-716c168d6bf3

Urn: uri:34ba0527-dfd1-42aa-9f2c-716c168d6bf3

Pubs-id: pubs:648298 Item Description

Type: journal-article;

Language: ENG

Version: Publisher's VersionKeywords: chromosomes genes mouse

Relationships





Autor: Rose, Nathan R. - Oxford, MSD, Biochemistry - - - King, Hamish W. - Oxford, MSD, Biochemistry - - - Blackledge, Neil P. - Oxford,

Fuente: https://ora.ox.ac.uk/objects/uuid:34ba0527-dfd1-42aa-9f2c-716c168d6bf3



DESCARGAR PDF




Documentos relacionados