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Reference: Barron, HC, Garvert, MM and Behrens, TEJ, (2016). Repetition suppression: a means to index neural representations using BOLD?. Philosophical Transactions B: Biological Sciences, 371 (1705), Article: 20150355.Citable link to this page:


Repetition suppression: a means to index neural representations using BOLD?

Abstract: Understanding how the human brain gives rise to complex cognitive processes remains one of the biggest challenges of contemporary neuroscience. While invasive recording in animal models can provide insight into neural processes that are conserved across species, our understanding of cognition more broadly relies upon investigation of the human brain itself. There is therefore an imperative to establish non-invasive tools that allow human brain activity to be measured at high spatial and temporal resolution. In recent years, various attempts have been made to refine the coarse signal available in functional magnetic resonance imaging (fMRI), providing a means to investigate neural activity at the meso-scale, i.e. at the level of neural populations. The most widely used techniques include repetition suppression and multivariate pattern analysis. Human neuroscience can now use these techniques to investigate how representations are encoded across neural populations and transformed by relevant computations. Here, we review the physiological basis, applications and limitations of fMRI repetition suppression with a brief comparison to multivariate techniques. By doing so, we show how fMRI repetition suppression holds promise as a tool to reveal complex neural mechanisms that underlie human cognitive function.This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionNotes:Copyright © 2016 The Authors.Published by the Royal Society under the terms of the Creative Commons Attribution License, which permits unrestricted use, provided the original author and source are credited.

Bibliographic Details

Publisher: Royal Society

Publisher Website:

Journal: Philosophical Transactions B: Biological Sciencessee more from them

Publication Website:

Volume: 371

Issue: 1705

Extent: Article: 20150355

Issue Date: 2016

pages:Article: 20150355Identifiers


Eissn: 1471-2970

Issn: 0962-8436

Uuid: uuid:79cd161c-7b39-4719-a103-19c84b318bb6

Urn: uri:79cd161c-7b39-4719-a103-19c84b318bb6

Pubs-id: pubs:642237 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: functional magnetic resonance imaging adaptation neural computation neural representation repetition suppression


Author: Barron, HC - Oxford oxfordCollegeMerton College - - - Garvert, MM - Oxford, MSD, Clinical Neurosciences fundingWellcome Trust - -



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