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Reference: Knight, JC, Koustoulidou, S and Cornelissen, B et al., (2017). Imaging the DNA damage response with PET and SPECT. European Journal of Nuclear Medicine and Molecular Imaging, 44 (6), 1065–1078.Citable link to this page:


Imaging the DNA damage response with PET and SPECT

Abstract: DNA integrity is constantly challenged by endogenous and exogenous factors that can alter the DNA sequence, leading to mutagenesis, aberrant transcriptional activity, and cytotoxicity. Left unrepaired, damaged DNA can ultimately lead to the development of cancer. To overcome this threat, a series of complex mechanisms collectively known as the DNA damage response (DDR) are able to detect the various types of DNA damage that can occur and stimulate the appropriate repair process. Each DNA damage repair pathway leads to the recruitment, upregulation, or activation of specific proteins within the nucleus, which, in some cases, can represent attractive targets for molecular imaging. Given the well-established involvement of DDR during tumorigenesis and cancer therapy, the ability to monitor these repair processes non-invasively using nuclear imaging techniques may facilitate the earlier detection of cancer and may also assist in monitoring response to DNA damaging treatment. This review article aims to provide an overview of recent efforts to develop PET and SPECT radiotracers for imaging of DNA damage repair proteins.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:16 December 2016 Funder: Cancer Research UK   Notes:Copyright © The Author(s) 2017Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Bibliographic Details

Publisher: Springer Berlin Heidelberg

Publisher Website:

Journal: European Journal of Nuclear Medicine and Molecular Imagingsee more from them

Publication Website:

Volume: 44

Issue: 6

Extent: 1065–1078

Issue Date: 2017



Issn: 1619-7070

Eissn: 1619-7089

Uuid: uuid:5449746c-2087-4626-8702-2a38f3b8d39a

Urn: uri:5449746c-2087-4626-8702-2a38f3b8d39a

Pubs-id: pubs:668643 Item Description

Type: journal-article;

Version: Publisher's versionKeywords: DNA damage PET SPECT molecular imaging γH2AX PARP


Autor: Knight, JC - Oxford, MSD, Oncology, CRUK-MRC Ox Inst for Radiation Oncology - - - Koustoulidou, S - Oxford, MSD, Oncology, CRUK-M



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