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Reference: Udalova, I, Mantovani, A and Feldmann, M et al., (2016). Macrophage heterogeneity in the context of rheumatoid arthritis. Nature Reviews Rheumatology, 12 (8), 472-485.Citable link to this page:


Macrophage heterogeneity in the context of rheumatoid arthritis

Abstract: Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The increase in the number of sublining macrophages in the synovium is an early hallmark of active rheumatic disease, and high numbers of macrophages are a prominent feature of inflammatory lesions. The degree of synovial macrophage infiltration correlates with the degree of joint erosion, and depletion of these macrophages from inflamed tissue has a profound therapeutic benefit. Research has now uncovered an unexpectedly high level of heterogeneity in macrophage origin and function, and has emphasized the role of environmental factors in their functional specialization. Although the heterogeneous populations of macrophages in RA have not been fully characterized, preliminary results in mouse models of arthritis have contributed to our understanding of the phenotype and ontogeny of synovial macrophages, and to deciphering the properties of monocyte-derived infiltrating and tissue-resident macrophages. Elucidating the molecular mechanisms that drive polarization of macrophages towards proinflammatory or anti-inflammatory phenotypes could lead to identification of signalling pathways that inform future therapeutic strategies.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Accepted ManuscriptDate of acceptance:18 May 2016

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website:

Journal: Nature Reviews Rheumatologysee more from them

Publication Website:

Volume: 12

Issue: 8

Issue Date: August 2016



Eissn: 1759-4804

Issn: 1759-4790

Uuid: uuid:a3dca7d1-7ad4-46db-a64a-473728a328ad

Urn: uri:a3dca7d1-7ad4-46db-a64a-473728a328ad

Pubs-id: pubs:634116 Item Description

Type: journal-article;

Language: eng

Version: Accepted ManuscriptKeywords: macrophages monocytes and macrophages rheumatoid arthritis


Autor: Udalova, I - Oxford, MSD, NDORMS, KIR fundingKennedy Institute Trustees' Research Fund fundingArthritis Research UK - - - Man



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