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Reference: Allin, BS, Irvine, A, Patni, N et al., (2016). Variability of outcome reporting in Hirschsprung's Disease and gastroschisis: a systematic review. Scientific Reports, 6, Article: 38969.Citable link to this page:

 

Variability of outcome reporting in Hirschsprung's Disease and gastroschisis: a systematic review

Abstract: Heterogeneity in outcome reporting limits identification of gold-standard treatments for Hirschsprung's Disease(HD) and gastroschisis. This review aimed to identify which outcomes are currently investigated in HD and gastroschisis research so as to counter this heterogeneity through informing development of a core outcome set(COS). Two systematic reviews were conducted. Studies were eligible for inclusion if they compared surgical interventions for primary treatment of HD in review one, and gastroschisis in review two. Studies available only as abstracts were excluded from analysis of reporting transparency. Thirty-five HD studies were eligible for inclusion in the review, and 74 unique outcomes were investigated. The most commonly investigated was faecal incontinence (32 studies, 91%). Seven of the 28 assessed studies (25%) met all criteria for transparent outcome reporting. Thirty gastroschisis studies were eligible for inclusion in the review, and 62 unique outcomes were investigated. The most commonly investigated was length of stay (24 studies, 80%). None of the assessed studies met all criteria for transparent outcome reporting. This review demonstrates that heterogeneity in outcome reporting and a significant risk of reporting bias exist in HD and gastroschisis research. Development of a COS could counter these problems, and the outcome lists developed from this review could be used in that process.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's version Funder: National Institute for Health Research   Notes:Copyright © 2016 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The imagesor other third party material in this article are included in the article’s Creative Commons license,unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,users will need to obtain permission from the license holder to reproduce the material. To view a copy of thislicense, visit http://creativecommons.org/licenses/by/4.0/

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website: http://www.nature.com/

Journal: Scientific Reportssee more from them

Publication Website: http://www.nature.com/srep

Volume: 6

Extent: Article: 38969

Issue Date: 12 December 2016

pages:Article: 38969Identifiers

Doi: https://doi.org/10.1038/srep38969

Issn: 2045-2322

Uuid: uuid:90859ba2-d686-4ccd-ac7b-46ba555b421c

Urn: uri:90859ba2-d686-4ccd-ac7b-46ba555b421c

Pubs-id: pubs:666163 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: outcomes research paediatric research

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Autor: Allin, BS - Oxford, MSD, Nuffield Department of Population Health, NPEU fundingNational Institute for Health Research - - - Irvin

Fuente: https://ora.ox.ac.uk/objects/uuid:90859ba2-d686-4ccd-ac7b-46ba555b421c



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