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Reference: Scholl, J, Kolling, N, Nelissen, N et al., (2017). Excitation and inhibition in anterior cingulate predict use of past experiences. eLife, 6.Citable link to this page:

 

Excitation and inhibition in anterior cingulate predict use of past experiences

Abstract: Dorsal anterior cingulate cortex (dACC) mediates updating and maintenance of cognitive models of the world used to drive adaptive reward-guided behavior. We investigated the neurochemical underpinnings of this process. We used magnetic resonance spectroscopy in humans, to measure levels of glutamate and GABA in dACC. We examined their relationship to neural signals in dACC, measured with fMRI, and cognitive task performance. Both inhibitory and excitatory neurotransmitters in dACC were predictive of the strength of neural signals in dACC and behavioral adaptation. Glutamate levels were correlated, first, with stronger neural activity representing information to be learnt about the tasks’ costs and benefits and, second, greater use of this information in the guidance of behavior. GABA levels were negatively correlated with the same neural signals and the same indices of behavioral influence. Our results suggest that glutamate and GABA in dACC affect the encoding and use of past experiences to guide behavior.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2016-11-29 Funder: Medical Research Council   Funder: Wellcome Trust   Funder: Christ Church College, Oxford   Notes:© Copyright Scholl et al. This article is distributed under the terms of the Creative Commons Attribution License.

Bibliographic Details

Publisher: eLife Sciences Publications

Publisher Website: http://elife.elifesciences.org/

Journal: eLifesee more from them

Publication Website: http://www.elifesciences.org/

Volume: 6

Issue Date: 2017-01-05

Article Number:e20365Identifiers

Doi: https://doi.org/10.7554/eLife.20365

Issn: 2050-084X

Uuid: uuid:3114a25a-3531-409c-a3a3-a10bc504f36f

Urn: uri:3114a25a-3531-409c-a3a3-a10bc504f36f

Pubs-id: pubs:668371 Item Description

Type: journal-article;

Version: Publisher's versionKeywords: dACC fMRI GABA glutamate Human learning spectroscopy

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Autor: Scholl, J - Oxford, MSD, Experimental Psychology Christ Church - - - Kolling, N - Oxford, MSD, Experimental Psychology - - - Neli

Fuente: https://ora.ox.ac.uk/objects/uuid:3114a25a-3531-409c-a3a3-a10bc504f36f



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