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Reference: Fletcher, NF, Clark, AR, Balfe, P et al., (2017). TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway. Journal of General Virology, 98, 405-412.Citable link to this page:

 

TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway.

Abstract: Preventing viral induced liver disease begins with an understanding 1 of the host factors that define susceptibility to infection. Hepatitis C Virus (HCV) is a global health issue with an estimated 170 million infected individuals at risk of developing liver disease including fibrosis and hepatocellular carcinoma. The liver is the major reservoir supporting HCV replication and this hepatocellular tropism is defined by HCV engagement of cellular entry receptors. Hepatocytes are polarised in vivo and this barrier function limits HCV entry. We previously reported that activated macrophages promote HCV entry into polarised hepatocytes via a TNF-α dependent process, however, the underlying mechanism was not defined. In this study we show that several TNF superfamily members, including TNF-α, TNF-β, TWEAK and LIGHT promote HCV entry via NF-κB mediated activation of myosin light chain kinase (MLCK) and disruption of tight junctions. These observations support a model where HCV hijacks an inflammatory immune response to stimulate infection and uncovers a role for NF-κB-MLCK signaling in maintaining hepatocellular tight junctions.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Accepted manusciptDate of acceptance:2016-12-15 Funder: Medical Research Council   Funder: Seventh Framework Programme   Funder: Arthritis Research UK   Notes:© 2017 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Bibliographic Details

Publisher: Microbiology Society

Publisher Website: http://www.microbiologyresearch.org/

Journal: Journal of General Virologysee more from them

Publication Website: http://jgv.microbiologyresearch.org/content/journal/jgv

Volume: 98

Issue Date: 7-03

pages:405-412Identifiers

Doi: https://doi.org/10.1099/jgv.0.000689

Eissn: 1465-2099

Issn: 0022-1317

Uuid: uuid:a680ece5-3baf-4a9e-8aef-b467771d14f0

Urn: uri:a680ece5-3baf-4a9e-8aef-b467771d14f0

Pubs-id: pubs:673502 Item Description

Type: journal-article;

Language: en

Version: Accepted manuscipt

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Autor: Fletcher, NF - - - Clark, AR - - - Balfe, P - - - McKeating, JA - facultyOxford, MSD, NDM, Target Discovery Institute - - - - Bib

Fuente: https://ora.ox.ac.uk/objects/uuid:a680ece5-3baf-4a9e-8aef-b467771d14f0



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