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Reference: Bharathavikru, R, Dudnakova, T, Aitken, S et al., (2017). Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction. Genes & Development, 31 (4), 347-352.Citable link to this page:

 

Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction.

Abstract: Wilms' tumor 1 (WT1) is essential for the development and homeostasis of multiple mesodermal tissues. Despite evidence for post-transcriptional roles, no endogenous WT1 target RNAs exist. Using RNA immunoprecipitation and UV cross-linking, we show that WT1 binds preferentially to 3' untranslated regions (UTRs) of developmental targets. These target mRNAs are down-regulated upon WT1 depletion in cell culture and developing kidney mesenchyme. Wt1 deletion leads to rapid turnover of specific mRNAs. WT1 regulates reporter gene expression through interaction with 3' UTR-binding sites. Combining experimental and computational analyses, we propose that WT1 influences key developmental and disease processes in part through regulating mRNA turnover.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2017-02-15 Funder: Medical Research Council   Notes:© 2017 Bharathavikru et al. This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/

Bibliographic Details

Publisher: Cold Spring Harbor Laboratory Press

Publisher Website: http://www.cshlp.org/

Journal: Genes & Developmentsee more from them

Publication Website: http://genesdev.cshlp.org/

Volume: 31

Issue: 4

Issue Date: 2017-03

pages:347-352Identifiers

Doi: https://doi.org/10.1101/gad.291500.116

Issn: 1549-5477

Uuid: uuid:3ae89b4e-d8f4-4188-bcf9-81e48075fa89

Urn: uri:3ae89b4e-d8f4-4188-bcf9-81e48075fa89

Pubs-id: pubs:687048 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: 3′ UTR FLASH RNA secondary structures WT1 developmental pathways hybrids

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Autor: Bharathavikru, R - - - Dudnakova, T - - - Aitken, S - - - Slight, J - - - Artibani, M - Oxford, MSD, RDM, RDM Clinical Laboratory

Fuente: https://ora.ox.ac.uk/objects/uuid:3ae89b4e-d8f4-4188-bcf9-81e48075fa89



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