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Reference: Areias, MCC, Shimizu, K and Compton, RG et al., (2016). Voltammetric detection of glutathione; an adsorptive stripping voltammetry approach. Analyst, 141, 2904-2910.Citable link to this page:

 

Voltammetric detection of glutathione; an adsorptive stripping voltammetry approach

Abstract: A simple, sensitive, and rapid detection of glutathione by cyclic voltammetry using a bare glassy carbon electrode is reported in which glutathione forms a 1:1 complex compound with copper(II) ion. This complex compound is adsorbed onto the electrode surface and undergoes electrochemical oxidation at a characteristic oxidation potential of ca. - 0.20 V vs standard mercury/mercurous sulphate reference electrode, which is used to detect the glutathione concentration. The linear dynamic range is obtained for a glutathione concentration of 1 µM to 12.5 µM, and the sensitivity is found to be 0.1 ± 0.002 μA μM-1. The low limit of detection (n=3) of 0.14 μM and the precision of 1.8% are achieved using a simple, unmodified electrode. The robustness of the present methodology is demonstrated by the successful quantitative analysis of glutathione in the presence of cysteine.

Peer Review status:Peer reviewedPublication status:PublishedVersion:Accepted manuscriptNotes:Authors will always retain their copyright for articles published with the Royal Society of Chemistry. This is the accepted manuscript version of the article. The final version is available online from the Royal Society of Chemistry at: [10.1039/C6AN00550K]

Bibliographic Details

Publisher: Royal Society of Chemistry

Publisher Website: http://www.rsc.org/

Journal: Analystsee more from them

Publication Website: http://pubs.rsc.org/en/Journals/JournalIssues/AN

Volume: 141

Extent: 2904-2910

Issue Date: 2016-04-01

Article Number:

pages:2904-2910 Identifiers

Urn: uuid:68c73a20-c08f-4fc7-b9ec-e514ab0a99d0

Source identifier: 613087

Eissn: 1364-5528

Doi: https://doi.org/10.1039/C6AN00550K

Issn: 0003-2654 Item Description

Type: Journal article;

Version: Accepted manuscriptKeywords: copper(II) glutathione glassy carbon electrode thiols cyclic voltammetry Tiny URL: pubs:613087

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Autor: Areias, MCC - - - Shimizu, K - institutionUniversity of Oxford Oxford, MPLS, Chemistry, Physical and Theoretical Chem grantNumber

Fuente: https://ora.ox.ac.uk/objects/uuid:68c73a20-c08f-4fc7-b9ec-e514ab0a99d0



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