The antepartum stillbirth syndrome: risk factors and pregnancy conditions identified in the INTERGROWTH-21st ProjectReportar como inadecuado




The antepartum stillbirth syndrome: risk factors and pregnancy conditions identified in the INTERGROWTH-21st Project - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Reference: Hirst, JE, Villar, J, Victora, CG et al., (2016). The antepartum stillbirth syndrome: risk factors and pregnancy conditions identified in the INTERGROWTH-21st Project. BJOG: an International Journal of Obstetrics and Gynaecology.Citable link to this page:

 

The antepartum stillbirth syndrome: risk factors and pregnancy conditions identified in the INTERGROWTH-21st Project

Abstract: Objectives: We aimed to identify risk factors for antepartum stillbirth including fetal growth restriction, amongst women with well-dated pregnancies and access to antenatal care. Design: Population-based, prospective, observational studySetting: Eight international urban populations Population: Pregnant women and their babies enrolled in the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. Methods: Cox proportional Hazard models were used to compare risks amongst antepartum stillborn and liveborn babies.Main outcome measures: Antepartum stillbirth was defined as any fetal death after 16 weeks of gestation before the onset of labour. Results: Of 60 121 babies, 553 were stillborn (9.2 per 1000 births), of which 445 were antepartum deaths (7.4 per 1000 births). After adjustment for site, risk factors were low socio-economic status, Hazard ratio (HR): 1·6 (95% CI 1·2-2·1); single marital status, 2·0 (1·4-2·8); age  40 years, 2·2 (1·4-3·7); essential hypertension 4·0 (2·7-5·9); HIV/AIDS 4·3 (2·0-9·1); preeclampsia 1·6 (1·1-3·8), multiple pregnancy 3·3 (2.0-5·6) and antepartum haemorrhage 3.3 (2.5-4.5). Birth weight < 3rd centile was associated with antepartum stillbirth, 4.6 (3.4-6.2). The greatest risk was in babies not suspected to have been growth restricted antenatally, 5.0 (3.6-7.0). The population attributable risk of antepartum death associated with SGA diagnosed at birth was 11%. Conclusions: Antepartum stillbirth is a complex syndrome associated with several risk factors. Although small babies are at higher risk, current growth restriction detection strategies only modestly reduced the rate of stillbirth.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:25 October 2016 Funder: Bill and Melinda Gates Foundation   Notes:Copyright © 2016 The Authors. BJOG An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and GynaecologistsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Bibliographic Details

Publisher: Wiley

Publisher Website: http://onlinelibrary.wiley.com/

Journal: BJOG: an International Journal of Obstetrics and Gynaecologysee more from them

Publication Website: http://obgyn.onlinelibrary.wiley.com/hub/journal/10.1111/(ISSN)1471-0528/

Issue Date: 2016Identifiers

Issn: 1470-0328

Eissn: 1471-0528

Uuid: uuid:88e4e6a7-d36a-4b07-9dd0-fb2bfe1c2f1b

Urn: uri:88e4e6a7-d36a-4b07-9dd0-fb2bfe1c2f1b

Pubs-id: pubs:656712

Doi: https://doi.org/10.1111/1471-0528.14463 Item Description

Type: journal-article;

Version: Publisher's versionKeywords: antepartum stillbirth birth weight fetal growth restriction INTERGROWTH-21st

Relationships





Autor: Hirst, JE - Oxford, MSD, Obstetrics and Gynaecology - - - Villar, J - Oxford, MSD, Obstetrics and Gynaecology - - - Victora, CG -

Fuente: https://ora.ox.ac.uk/objects/uuid:88e4e6a7-d36a-4b07-9dd0-fb2bfe1c2f1b



DESCARGAR PDF




Documentos relacionados