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Reference: Ip, IB, Berrington, A, Hess, AT et al., (2017). Combined fMRI-MRS acquires simultaneous glutamate and BOLD-fMRI signals in the human brain. Neuroimage, 155, 113–119.Citable link to this page:

 

Combined fMRI-MRS acquires simultaneous glutamate and BOLD-fMRI signals in the human brain

Abstract: Combined fMRI-MRS is a novel method to non-invasively investigate functional activation in the human brain using simultaneous acquisition of hemodynamic and neurochemical measures. The aim of the current study was to quantify neural activity using combined fMRI-MRS at 7 T. BOLD-fMRI and semi-LASER localization MRS data were acquired from the visual cortex of 13 participants during short blocks (64s) of flickering checkerboards. We demonstrate a correlation between glutamate and BOLD-fMRI time courses (R = 0.381, p =0.031). In addition, we show increases in BOLD-fMRI (1.43 ± 0.17%) and glutamate concentrations (0.15 ± 0.05 I.U., ~2%) during visual stimulation. In contrast, we observed no change in glutamate concentrations in resting state MRS data during sham stimulation periods. Spectral line width changes generated by the BOLD-response were corrected using line broadening. In summary, our results establish the feasibility of concurrent measurements of BOLD-fMRI and neurochemicals using a novel combined fMRI-MRS sequence. Our findings strengthen the link between glutamate and functional activity in the human brain by demonstrating a significant correlation of BOLD-fMRI and glutamate over time, and by showing ~2% glutamate increases during 64s of visual stimulation. Our tool may become useful for studies characterizing functional dynamics between neurochemicals and hemodynamics in health and disease.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:13 April 2017 Funder: Medical Research Council   Funder: Royal Society   Funder: Wellcome Trust   Notes:Copyright © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)

Bibliographic Details

Publisher: Elsevier

Publisher Website: http://www.elsevier.com/

Journal: Neuroimagesee more from them

Publication Website: https://www.journals.elsevier.com/neuroimage

Volume: 155

Extent: 113–119

Issue Date: 18 April 2017

pages:113–119Identifiers

Doi: https://doi.org/10.1016/j.neuroimage.2017.04.030

Eissn: 1095-9572

Issn: 1053-8119

Uuid: uuid:d5e5aa7c-6456-4771-8b59-b3392780400e

Urn: uri:d5e5aa7c-6456-4771-8b59-b3392780400e

Pubs-id: pubs:691102 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: functional spectroscopy BOLD fMRI glutamate neurochemistry visual cortex

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Autor: Ip, IB - Oxford, MSD, Physiology Anatomy and Genetics - - - Berrington, A - Oxford, MSD, Clinical Neurosciences - - - Hess, AT -

Fuente: https://ora.ox.ac.uk/objects/uuid:d5e5aa7c-6456-4771-8b59-b3392780400e



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