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Reference: Colin-York, H, Shrestha, D, Felce, JH et al., (2016). Super-Resolved Traction Force Microscopy (STFM). Nano Letters, 16 (4), 2633-2638.Citable link to this page:


Super-Resolved Traction Force Microscopy (STFM).

Abstract: Measuring small forces is a major challenge in cell biology. Here we improve the spatial resolution and accuracy of force reconstruction of the well-established technique of traction force microscopy (TFM) using STED microscopy. The increased spatial resolution of STED-TFM (STFM) allows a greater than 5-fold higher sampling of the forces generated by the cell than conventional TFM, accessing the nano instead of the micron scale. This improvement is highlighted by computer simulations and an activating RBL cell model system.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2016-02-25 Funder: Medical Research Council   Funder: Biotechnology and Biological Sciences Research Council   Funder: Engineering and Physical Sciences Research Council   Funder: Wellcome Trust   Funder: Wolfson Foundation   Notes:© 2016 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.

Bibliographic Details

Publisher: American Chemical Society

Publisher Website:

Journal: Nano Letterssee more from them

Publication Website:

Volume: 16

Issue: 4

Issue Date: 2016-02



Issn: 1530-6992

Issn: 1530-6984

Uuid: uuid:9bcafc29-32da-4fff-b27d-2b05d432d28a

Urn: uri:9bcafc29-32da-4fff-b27d-2b05d432d28a

Pubs-id: pubs:609109 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: Super-resolution microscopy actin cytoskeleton mechanobiology traction force microscopy Algorithms Cell Adhesion Computer Simulation Microscopy, Fluorescence Microscopy, Scanning Probe Models, Theoretical Stress, Mechanical Traction


Autor: Colin-York, H - - - Shrestha, D - - - Felce, JH - Oxford, MSD, RDM, RDM - Investigative Medicine Division - - - Waithe, D - - - M



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