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Reference: Philippaert, K, Pironet, A, Mesuere, M et al., (2017). Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. Nature Communications, 8, 14733.Citable link to this page:

 

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Abstract: Steviol glycosides (SGs), such as stevioside and rebaudioside A, are natural, non-caloric sweet-tasting organic molecules, present in extracts of the scrub plant Stevia rebaudiana, which are widely used as sweeteners in consumer foods and beverages. TRPM5 is a Ca(2+)-activated cation channel expressed in type II taste receptor cells and pancreatic β-cells. Here we show that stevioside, rebaudioside A and their aglycon steviol potentiate the activity of TRPM5. We find that SGs potentiate perception of bitter, sweet and umami taste, and enhance glucose-induced insulin secretion in a Trpm5-dependent manner. Daily consumption of stevioside prevents development of high-fat-diet-induced diabetic hyperglycaemia in wild-type mice, but not in Trpm5(-/-) mice. These results elucidate a molecular mechanism of action of SGs and identify TRPM5 as a potential target to prevent and treat type 2 diabetes.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2017-01-26 Funder: FWO Vlaanderen   Funder: Belgian Federal Government   Funder: KU Leuven   Notes:This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website: https://www.nature.com/

Journal: Nature Communicationssee more from them

Publication Website: https://www.nature.com/ncomms/

Volume: 8

Issue Date: 2017-03-31

pages:14733Identifiers

Doi: https://doi.org/10.1038/ncomms14733

Issn: 2041-1723

Uuid: uuid:9e110f5c-04a2-43ca-8b13-2270b4128d6f

Urn: uri:9e110f5c-04a2-43ca-8b13-2270b4128d6f

Pubs-id: pubs:689598 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: Journal Article

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Autor: Philippaert, K - - - Pironet, A - - - Mesuere, M - - - Sones, W - Oxford, MSD, NDORMS, CSM - - - Vermeiren, L - - - Kerselaers, S

Fuente: https://ora.ox.ac.uk/objects/uuid:9e110f5c-04a2-43ca-8b13-2270b4128d6f



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