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Reference: Lupton, MK, Benyamin, B, Proitsi, P et al., (2017). No genetic overlap between circulating iron levels and Alzheimer's disease. Journal of Alzheimer's Diseases, 59 (1), 85-99.Citable link to this page:

 

No genetic overlap between circulating iron levels and Alzheimer's disease

Abstract: Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Accepted ManuscriptNotes:Copyright © 2017 – IOS Press and the authors. This is the accepted manuscript version of the article. The final version is available online from IOS Press at: https://doi.org/10.3233/JAD-170027Please see the full text article for full list of funders.

Bibliographic Details

Publisher: IOS Press

Publisher Website: http://www.iospress.nl/

Journal: Journal of Alzheimer's Diseasessee more from them

Publication Website: http://www.iospress.nl/journal/journal-of-alzheimers-disease/

Volume: 59

Issue: 1

Extent: 85-99

Issue Date: 2017-07-03

pages:85-99Identifiers

Doi: https://doi.org/10.3233/JAD-170027

Eissn: 1875-8908

Issn: 1387-2877

Uuid: uuid:671aae93-8727-4701-bb74-d83f8f8fe771

Urn: uri:671aae93-8727-4701-bb74-d83f8f8fe771

Pubs-id: pubs:700440 Item Description

Type: journal-article;

Language: eng

Version: Accepted ManuscriptKeywords: Alzheimer’s disease apolipoproteins E dementia ferritin genetic profile scores genome-wide association study iron population genetics transferrin

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Autor: Lupton, MK - - - Benyamin, B - - - Proitsi, P - - - Nyholt, DR - - - Ferreira, MA - - - Montgomery, GW - - - Heath, AC - - - Madd

Fuente: https://ora.ox.ac.uk/objects/uuid:671aae93-8727-4701-bb74-d83f8f8fe771



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