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Reference: Grotz, AK, Gloyn, AL and Thomsen, SK et al., (2017). Prioritizing causal genes at type 2 diabetes risk loci. Current Diabetes Reports, 17 (9), Article: 76.Citable link to this page:

 

Prioritizing causal genes at type 2 diabetes risk loci

Abstract: Purpose of review: Genome-wide association studies (GWAS) for type 2 diabetes (T2D) risk have identified a large number of genetic loci associated with disease susceptibility. However, progress moving from association signals through causal genes to functional understanding has so far been slow, hindering clinical translation. This review discusses the benefits and limitations of emerging, unbiased approaches for prioritizing causal genes at T2D risk loci.Recent findings: Candidate causal genes can be identified by a number of different strategies that rely on genetic data, genomic annotations, and functional screening of selected genes. To overcome the limitations of each particular method, integration of multiple data sets is proving essential for establishing confidence in the prioritised genes. Previous studies have also highlighted the need to support these efforts through identification of causal variants and disease-relevant tissues.Summary: Prioritization of causal genes at T2D risk loci by integrating complementary lines of evidence promises to accelerate our understanding of disease pathology and promote translation into new therapeutics.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:29 June 2017Notes:Copyright © 2017 The Authors.This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Bibliographic Details

Publisher: Springer US

Publisher Website: https://www.springer.com/

Journal: Current Diabetes Reportssee more from them

Publication Website: https://link.springer.com/journal/11892

Volume: 17

Issue: 9

Extent: Article: 76

Issue Date: 2017-07-31

pages:Article: 76Identifiers

Doi: https://doi.org/10.1007/s11892-017-0907-y

Issn: 1534-4827

Eissn: 1539-0829

Uuid: uuid:02b419f4-3b11-492e-ba82-59c9ab9c6f37

Urn: uri:02b419f4-3b11-492e-ba82-59c9ab9c6f37

Pubs-id: pubs:710160 Item Description

Type: journal-article;

Version: Publisher's versionKeywords: genome-wide association study type 2 diabetes genetic mechanism functional genomics causal gene effector transcript

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Autor: Grotz, AK - Oxford, MSD, RDM fundingWellcome Trust grantNumberSenior Fellow in Basic Biomedical Science 095101-Z-10-Z and 200837-

Fuente: https://ora.ox.ac.uk/objects/uuid:02b419f4-3b11-492e-ba82-59c9ab9c6f37



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