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Reference: Nair, M, Knight, M and McCall, SJ et al., (2016). Factors associated with maternal mortality at advanced maternal age: a population-based case-control study. BJOG: An International Journal of Obstetrics and Gynaecology, 124 (8), 1225–1233.Citable link to this page:

 

Factors associated with maternal mortality at advanced maternal age: a population-based case-control study

Abstract: Objective: This study aimed to examine the factors associated with maternal mortality among women aged ≥35 years. Design: Unmatched population based case-control study Setting: United Kingdom Population: Between 2009-2012, 105 cases of maternal deaths aged ≥35 years were extracted from the surveillance database of the MBRRACE-UK confidential enquiries into maternal deaths in the UK. In addition, 766 controls aged ≥35 years were identified from the UK Obstetric Surveillance System (2005-2012). Methods: Risk factors known to be associated with maternal mortality and morbidity and for which data were available were examined for their association with maternal mortality among women ≥35 years using logistic regression analysis. Outcome measures: Odds ratios and 95% confidence intervals associated with maternal death. Results: Five factors were found to be significantly associated with increased odds of death among women aged ≥35 years: smoking during pregnancy (adjusted odds ratio (aOR) 2.06, 95% CI 1.13-3.75), inadequate use of antenatal care (aOR 23.62, 95%CI 8.79-63.45), medical comorbidities (aOR 5.92, 95%CI:3.56-9.86) and previous pregnancy problems (aOR:2.06(95%CI:1.23-3.45). The odds associated with death increased by 12% per year increase in age (aOR 1.12, 95% CI 1.02-1.22). Conclusion: Age was associated with maternal mortality even after adjusting for other known risk factors. Importantly, this study showed an association between maternal mortality and smoking among women aged 35 years or older. It emphasizes 3 the importance of public health action to reduce smoking levels and address trends in rising maternal age.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's version Funder: Department of Health   Notes:© 2016 The Authors. BJOG An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.

Bibliographic Details

Publisher: Wiley

Publisher Website: http://eu.wiley.com/WileyCDA/

Journal: BJOG: An International Journal of Obstetrics and Gynaecologysee more from them

Publication Website: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1471-0528

Volume: 124

Issue: 8

Extent: 1225–1233

Issue Date: 2016-07-13

pages:1225–1233Identifiers

Urn: uuid:3dc4e505-75a1-43b1-95ae-5bde089423db

Source identifier: 623000

Eissn: 1471-0528

Issn: 1470-0328

Doi: https://doi.org/10.1111/1471-0528.14216 Item Description

Type: Journal article;

Version: Publisher's versionKeywords: advanced maternal age maternal mortality risk factors smoking Tiny URL: pubs:623000

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Autor: Nair, M - institutionUniversity of Oxford Oxford, MSD, Nuffield Department of Population Health, NPEU - - - Knight, M - instituti

Fuente: https://ora.ox.ac.uk/objects/uuid:3dc4e505-75a1-43b1-95ae-5bde089423db



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