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Reference: Greenhalgh, T, Ovseiko, PV, Fahy, N et al., (2017). Maximising value from a United Kingdom Biomedical Research Centre: study protocol. Health Research Policy and Systems, 15 (1), Article: 70.Citable link to this page:


Maximising value from a United Kingdom Biomedical Research Centre: study protocol

Abstract: BackgroundBiomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country’s international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) apply the evidence base on how best to support the various partnerships in this large, multi-stakeholder research system and (2) research how these partnerships play out in a new, ambitious programme of translational research.MethodsOrganisational case study, informed by the principles of action research. A cross-cutting theme, ‘Partnerships for Health, Wealth and Innovation’ has been established with multiple sub-themes (drug development, device development, business support and commercialisation, research methodology and statistics, health economics, bioethics, patient and public involvement and engagement, knowledge translation, and education and training) to support individual BRC research themes and generate cross-theme learning.The ‘Partnerships’ theme will support the BRC’s goals by facilitating six types of partnership (with patients and citizens, clinical services, industry, across the NIHR infrastructure, across academic disciplines, and with policymakers and payers) through a range of engagement platforms and activities. We will develop a longitudinal progress narrative centred around exemplar case studies, and apply theoretical models from innovation studies (Triple Helix), sociology of science (Mode 2 knowledge production) and business studies (Value Co-creation). Data sources will be the empirical research studies within individual BRC research themes (who will apply separately for NHS ethics approval), plus documentary analysis and interviews and ethnography with research stakeholders. This study has received ethics clearance through the University of Oxford Central University Research Ethics Committee.DiscussionWe anticipate that this work will add significant value to Oxford BRC. We predict accelerated knowledge translation; closer alignment of the innovation process with patient priorities and the principles of responsible, ethical research; reduction in research waste; new knowledge about the governance and activities of multi-stakeholder research partnerships and the contexts in which they operate; and capacity-building that reflects the future needs of a rapidly-evolving health research system.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's version Funder: National Institute for Health Research   Notes:Copyright © 2017 The Authors. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Bibliographic Details

Publisher: Biomed Central

Publisher Website:

Journal: Health Research Policy and Systemssee more from them

Publication Website:

Volume: 15

Issue: 1

Extent: Article: 70

Issue Date: 14 August 2017

pages:Article: 70Identifiers


Uuid: uuid:02394c67-6fad-4d8f-a006-33ec9052c8a9

Urn: uri:02394c67-6fad-4d8f-a006-33ec9052c8a9

Pubs-id: pubs:715320

Issn: 1478-4505 Item Description

Type: journal-article;

Version: Publisher's versionKeywords: innovation policy health policy health research policy health technology development National Institute for Health Research Biomedical Research Centres research partnerships research on research knowledge production


Autor: Greenhalgh, T - Oxford, MSD, Primary Care Health Sciences fundingRockefeller Foundation fundingNational Institute for Health Rese



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