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Reference: Colloca, L, Ludman, T, Bouhassira, D et al., (2017). Neuropathic pain. Nature Reviews Disease Primers, 33 (17002), 1-19.Citable link to this page:


Neuropathic pain

Abstract: Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7-10% of the general population. Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy. Indeed, imbalances between excitatory and inhibitory somatosensory signalling, alterations in ion channels and variability in the way that pain messages are modulated in the central nervous system all have been implicated in neuropathic pain. The burden of chronic neuropathic pain seems to be related to the complexity of neuropathic symptoms, poor outcomes and difficult treatment decisions. Importantly, quality of life is impaired in patients with neuropathic pain owing to increased drug prescriptions and visits to health care providers, as well as the morbidity from the pain itself and the inciting disease. Despite challenges, progress in the understanding of the pathophysiology of neuropathic pain is spurring the development of new diagnostic procedures and personalized interventions, which emphasize the need for a multidisciplinary approach to the management of neuropathic pain.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Accepted manuscriptDate of acceptance:2017-01-06Notes:This is the author accepted manuscript following peer review version of the article. The final version is available online from Nature Publishing Group at: 10.1038/nrdp.2017.2

Bibliographic Details

Publisher: Nature Publishing Group

Publisher Website:

Journal: Nature Reviews Disease Primerssee more from them

Publication Website:

Volume: 3

Issue: 17002

Issue Date: 2017-02-16



Issn: 2056-676X

Uuid: uuid:01aff05f-30b5-4b28-83e1-4f26c4782998

Urn: uri:01aff05f-30b5-4b28-83e1-4f26c4782998

Pubs-id: pubs:680827 Item Description

Type: journal-article;

Language: eng

Version: Accepted manuscriptKeywords: neuropathic pain pain pain management peripheral neuropathies


Author: Colloca, L - fundingUS National Institutes of Health grantNumberR01DE025946 - - - Ludman, T - - - Bouhassira, D - - - Baron, R -



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