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Reference: Penz, E, Watt, KN, Hergott, CA et al., (2017). Management of malignant pleural effusion: challenges and solutions. Cancer Management and Research, 9, 229-241.Citable link to this page:


Management of malignant pleural effusion: challenges and solutions

Abstract: Malignant pleural effusion (MPE) is a sign of advanced cancer and is associated with significant symptom burden and mortality. To date, management has been palliative in nature with a focus on draining the pleural space, with therapies aimed at preventing recurrence or providing intermittent drainage through indwelling catheters. Given that patients with MPEs are heterogeneous with respect to their cancer type and response to systemic therapy, functional status, and pleural milieu, response to MPE therapy is also heterogeneous and difficult to predict. Furthermore, the impact of therapies on important patient outcomes has only recently been evaluated consistently in clinical trials and cohort studies. In this review, we examine patient outcomes that have been studied to date, address the question of which are most important for managing patients, and review the literature related to the expected value for money (cost-effectiveness) of indwelling pleural catheters relative to traditionally recommended approaches.

Publication status:PublishedPeer Review status:Peer reviewedVersion:Publisher's versionDate of acceptance:2017-03-27Notes:© 2017 Penz et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (

Bibliographic Details

Publisher: Dove Medical Press

Publisher Website:

Journal: Cancer Management and Researchsee more from them

Publication Website:

Volume: 9

Extent: 229-241

Issue Date: 2017-06-23



Issn: 1179-1322

Eissn: 1179-1322

Uuid: uuid:b6528c64-1b87-4eeb-af42-8898b38b4a08

Urn: uri:b6528c64-1b87-4eeb-af42-8898b38b4a08

Pubs-id: pubs:704616 Item Description

Type: journal-article;

Language: eng

Version: Publisher's versionKeywords: cost-effectiveness malignant pleural effusion quality of life therapeutics


Author: Penz, E - - - Watt, KN - - - Hergott, CA - - - Rahman, NM - institutionUniversity of Oxford Oxford, MSD, NDM, NDM Experimental Me



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