The miR-17-92 MicroRNA Cluster regulates multiple components of the TGF-beta Pathway in neuroblastomaReportar como inadecuado




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(2010)MOLECULAR CELL.40(5).p.762-773 Mark abstract The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains elusive. Using SILAC and quantitative mass spectrometry, we examined the effects of activation of the miR-17-92 cluster on global protein expression in neuroblastoma (NB) cells. Our results reveal cooperation between individual miR-17-92 miRNAs and implicate miR-17-92 in multiple hallmarks of cancer, including proliferation and cell adhesion. Most importantly, we show that miR-17-92 is a potent inhibitor of TGF-beta signaling. By functioning both upstream and downstream of pSMAD2, miR-17-92 activation triggers downregulation of multiple key effectors along the TGF-beta signaling cascade as well as direct inhibition of TGF-beta-responsive genes.

Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1109485



Autor: Pieter Mestdagh , Anna-Karin Bostrom, Francis Impens , Erik Fredlund, Gert Van Peer, Pasqualino De Antonellis, Kristoffer von Sted

Fuente: https://biblio.ugent.be/publication/1109485



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