Inspiratory muscle training protocol for patients with chronic obstructive pulmonary disease IMTCO study: a multicentre randomised controlled trialReportar como inadecuado




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(2013)BMJ OPEN.3(8). Mark abstract Introduction: Inspiratory muscle training (IMT) has been applied during pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). However, it remains unclear if the addition of IMT to a general exercise training programme leads to additional clinically relevant improvements in patients with COPD. In this study, we will investigate whether the addition of IMT to a general exercise training programme improves 6 min walking distance, health-related quality of life, daily physical activity and inspiratory muscle function in patients with COPD with inspiratory muscle weakness.Methods and analysis: Patients with COPD (n=170) with inspiratory muscle weakness (Pi,max <60 cm H2O or <50%pred) will be recruited to a multicentre randomised placebo controlled trial of IMT and allocated into one of the two groups. Patients in both groups will follow a 3 month general exercise training programme, in combination with home-based IMT. IMT will be performed with a recently developed device (POWERbreathe KH1). This device applies an inspiratory load that is provided by an electronically controlled valve (variable flow resistive load). The intervention group (n=85) will undertake an IMT programme at a high intensity (≥50% of their Pi,max), whereas the placebo group (n=85) will undertake IMT at a low training intensity (≤10% of Pi,max). Total daily IMT time for both groups will be 21 min (6 cycles of 30 breaths). Improvement in the 6 min walking distance will be the primary outcome. Inspiratory muscle function, healthrelated quality of life and daily physical activity will be assessed as secondary outcomes.Ethics and dissemination: Ethics approval has been obtained from relevant centre committees and the study has been registered in a publicly accessible clinical trial database. The results will be easily interpretable and should immediately be communicated to healthcare providers, patients and the general public.Results: This can be incorporated into evidence-based treatment recommendations for clinical practice.

Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-4145635



Autor: Noppawan Charususin, Rik Gosselink, Marc Decramer, Alison McConnell, Didier Saey, Francois Maltais, Eric Derom , STEFANIE VERMEERS

Fuente: https://biblio.ugent.be/publication/4145635



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