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(2014)PLOS ONE.9(2). Mark abstract Environmental and genetic activation of a brain-adipocyte axis inhibits cancer progression. Leptin is the primary peripheral mediator of this anticancer effect in a mouse model of melanoma. In this study we assessed the effect of a leptin receptor antagonist on melanoma progression. Local administration of a neutralizing nanobody targeting the leptin receptor at low dose adjacent to tumor decreased tumor mass with no effects on body weight or food intake. In contrast, systemic administration of the nanobody failed to suppress tumor growth. Daily intraperitoneal injection of high-dose nanobody led to weight gain, hyperphagia, increased adiposity, hyperleptinemia, and hyperinsulinemia, and central effects mimicking leptin deficiency. The blockade of central actions of leptin by systemic delivery of nanobody may compromise its anticancer effect, underscoring the need to develop peripherally acting leptin antagonists coupled with efficient cancer-targeting delivery.

Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-4326617



Autor: Travis McMurphy, Run Xiao, Daniel Magee, Andrew Slater, Lennart Zabeau , Jan Tavernier and Lei Cao

Fuente: https://biblio.ugent.be/publication/4326617



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